Evidence map›Paper›PMID 26429098›Full record

ArticleNeuromuscular disorders : NMD2015

Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis.

Abby A McDonald, Sadie L Hebert, Linda K McLoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromuscular disorders : NMD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Skeletal muscle in health and disease.Disease models & mechanisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abby A McDonaldDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Molecular, Cellular, Developmental Biology and Genetics, University of Minnesota, Minneapolis, MN, USA.
Sadie L HebertDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Linda K McLoonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA; Graduate Program in Molecular, Cellular, Developmental Biology and Genetics, University of Minnesota, Minneapolis, MN, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA. Electronic address: mcloo001@umn.edu.
University of Minnesota · US

Funding

VISUAL NEUROSCIENCE TRAINING PROGRAMT32EY007133 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCLOON, STEVEN C · 1991 to 2010
$2.0M
Myogenic Potential of Extraocular Muscle Satellite CellsR21EY019620 · NEI · UNIVERSITY OF MINNESOTA · PI MCLOON, LINDA K. · 2009 to 2010
$376k
NEI NIH HHS EY11375NEI NIH HHS EY55137NEI NIH HHS R21 EY019620NEI NIH HHS T32 EY007133NEI NIH HHS T32EY007133NIAMS NIH HHS P30-AR0507220
6 · The paper itself

Abstract

Sparing of the extraocular muscles in muscular dystrophy is controversial. To address the potential role of utrophin in this sparing, mdx:utrophin(+/-) and mdx:utrophin(-/-) mice were examined for changes in myofiber size, central nucleation, and Pax7-positive and MyoD-positive cell density at intervals over their life span. Known to be spared in the mdx mouse, and contrary to previous reports, the extraocular muscles from both the mdx:utrophin(+/-) and mdx:utrophin(-/-) mice were also morphologically spared. In the mdx:utrophin(+/)(-) mice, which have a normal life span compared to the mdx:utrophin(-/-) mice, the myofibers were larger at 3 and 12 months than the wild type age-matched eye muscles. While there was a significant increase in central nucleation in the extraocular muscles from all mdx:utrophin(+/)(-) mice, the levels were still very low compared to age-matched limb skeletal muscles. Pax7- and MyoD-positive myogenic precursor cell populations were retained and were similar to age-matched wild type controls. These results support the hypothesis that utrophin is not involved in extraocular muscle sparing in these genotypes. In addition, it appears that these muscles retain the myogenic precursors that would allow them to maintain their regenerative capacity and normal morphology over a lifetime even in these more severe models of muscular dystrophy.

Indexed as

AgingAnimalsCollagenFibrosisImage Processing, Computer-AssistedImmunohistochemistryMice, Inbred mdxMuscle, SkeletalMyoD ProteinOculomotor MusclesOrgan SizePAX7 Transcription FactorUtrophinCollagenMyoD1 myogenic differentiation proteinMyoD ProteinPax7 protein, mousePAX7 Transcription FactorUtrophinExtraocular muscleMuscular dystrophyMyoDPax7Satellite cellUtrophin

Identifiers

PMID26429098
PMCPMC4630113
OpenAlexW2120287862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.