Evidence map›Paper›PMID 26428618›Full record

ReviewAdvanced drug delivery reviews2016

In vitro cardiac tissue models: Current status and future prospects.

Anurag Mathur, Zhen Ma, Peter Loskill, Shaheen Jeeawoody, Kevin E Healy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

  1. Article
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  8. Stimuli-responsive hybrid materials for 4DMaterials today. Bio · 2025
    Review
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anurag MathurDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
Zhen MaDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
Peter LoskillDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
Shaheen JeeawoodyDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Kevin E HealyDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA. Electronic address: kehealy@berkeley.edu.

Funding

Modeling metabolic interactions of liver and fat with integrated microphysiological systemsUH3TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2014 to 2016
$2.9M
Disease-Specific Integrated Microphysiological Human Tissue ModelsUH2TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, LEE, LUKE P. · 2012 to 2013
$1.8M
Enabling Technologies for hES Cell Self-RenewalR01HL096525 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2009 to 2013
$1.8M
Nanopatterned Surfaces to Control Cell FateR21EB005812 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2005 to 2006
$378k
iPSC Derived Cardiac Microchambers for Embryonic Drug ScreeningR21EB021003 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2015 to 2016
$353k
NCATS NIH HHS UH2 TR000487NCATS NIH HHS UH2TR000487NCATS NIH HHS UH3 TR000487NCATS NIH HHS UH3TR000487NHLBI NIH HHS NIH R01HL096525NHLBI NIH HHS R01 HL096525NIBIB NIH HHS R21 EB005812NIBIB NIH HHS R21 EB021003NIBIB NIH HHS R21 EB21003
6 · The paper itself

Abstract

Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.

Indexed as

Models, CardiovascularAnimalsBiocompatible MaterialsEmbryonic Stem CellsHeartHumansHydrogelsMyocytes, CardiacTissue EngineeringTissue ScaffoldsBiocompatible MaterialsHydrogelsBiomaterialsCardiac tissue modelsDisease modelingDrug screeningIn vitro cardiac tissue engineeringRegenerative medicineTissue engineering

Identifiers

PMID26428618
PMCPMC4832980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.