SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2016
Sensitivity, Specificity, and Posttest Probability of Parotid Fine-Needle Aspiration: A Systematic Review and Meta-analysis.
Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03849482 (Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms), which is not on this map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms
Who cites it
76 citing papers in PubMed, 182 citations in OpenAlex.
- Machine learning-based radiomics for histological classification of parotid tumors using morphological MRI: a comparative study.European radiology · 2022Trial
- Parotid pleomorphic adenoma: can a biopsy be omitted in the setting of a characteristic MRI?Oral radiology · 2026Article
- Deep Learning-Assisted MRI for Differentiating Parotid Gland Tumors: Comparison with FNAB and Radiologic Assessment.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound-enhanced fine-needle aspiration biopsy improves yield of solid benign parotid gland tumor tissue: a pilot study.European radiology experimental · 2026Article
- Could a multimodal fusion model integrating CT radiomics and systemic inflammatory markers improve preoperative risk stratification of parotid masses? A retrospective exploratory study.Frontiers in immunology · 2026Article
- Prognostic Factors in Salivary Gland Malignancies: A Multicenter Study of 229 Patients from the Polish Salivary Network Database.Journal of clinical medicine · 2025Article
- Clinical Significance of Incidentally Detected Parotid Masses on Brain MRI and PET-CT.Diagnostics (Basel, Switzerland) · 2025Article
- Bibliometric Analysis of the 100 Most Cited Systematic Reviews and Meta-Analysis in Oral Pathology.Cureus · 2025Review
- Article
- A Novel Training Model to Improve Diagnostic Accuracy of Cervical Fine-Needle Aspiration.Head & neck · 2025Article
- Ultrasound-enhanced fine-needle biopsy improves tissue yield in head and neck tumors ex vivo.Scientific reports · 2025Article
- Frozen Section Analysis in Submandibular Gland Tumors: Optimizing Intraoperative Decision-Making.Cancers · 2025Article
- Gold-Nanoparticles Reflectance Discriminates Benign from Malignant Salivary Gland Neoplasms.Journal of clinical medicine · 2025Article
- Comparative Diagnostic Accuracy of Ultrasound, MRI, and Fine-Needle Aspiration Biopsy in the Preoperative Evaluation of Parotid Gland Tumors.Journal of clinical medicine · 2025Article
- Applying deep learning-based ensemble model to [Japanese journal of radiology · 2025Article
- The Milan system for reporting salivary gland cytopathology and cyto-histological correlation with special emphasis on cystic lesions-4 years study in a tertiary care institute.Ecancermedicalscience · 2025Article
- Prediction of malignant risk stratification model for parotid gland nodules based on clinical and conventional ultrasound features: construction and validation.Gland surgery · 2024Article
- Evaluation of the anterior processes of the parotid gland: an ultrasonographic study.Surgical and radiologic anatomy : SRA · 2024Article
- Article
- Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study.BMC cancer · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectives(1) To analyze the sensitivity and specificity of fine-needle aspiration (FNA) in distinguishing benign from malignant parotid disease. (2) To determine the anticipated posttest probability of malignancy and probability of nondiagnostic and indeterminate cytology with parotid FNA. DATA SOURCES: Independently corroborated computerized searches of PubMed, Embase, and Cochrane Central Register were performed. These were supplemented with manual searches and input from content experts. REVIEW
methodsInclusion/exclusion criteria specified diagnosis of parotid mass, intervention with both FNA and surgical excision, and enumeration of both cytologic and surgical histopathologic results. The primary outcomes were sensitivity, specificity, and posttest probability of malignancy. Heterogeneity was evaluated with the I(2) statistic. Meta-analysis was performed via a 2-level mixed logistic regression model. Bayesian nomograms were plotted via pooled likelihood ratios.
resultsThe systematic review yielded 70 criterion-meeting studies, 63 of which contained data that allowed for computation of numerical outcomes (n = 5647 patients; level 2a) and consideration of meta-analysis. Subgroup analyses were performed in studies that were prospective, involved consecutive patients, described the FNA technique utilized, and used ultrasound guidance. The I(2) point estimate was >70% for all analyses, except within prospectively obtained and ultrasound-guided results. Among the prospective subgroup, the pooled analysis demonstrated a sensitivity of 0.882 (95% confidence interval [95% CI], 0.509-0.982) and a specificity of 0.995 (95% CI, 0.960-0.999). The probabilities of nondiagnostic and indeterminate cytology were 0.053 (95% CI, 0.030-0.075) and 0.147 (95% CI, 0.106-0.188), respectively.
conclusionFNA has moderate sensitivity and high specificity in differentiating malignant from benign parotid lesions. Considerable heterogeneity is present among studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.