Evidence map›Paper›PMID 26428375›Full record

ReviewCurrent topics in microbiology and immunology2015

EBV Noncoding RNAs.

Rebecca L Skalsky, Bryan R Cullen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in microbiology and immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 95 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rebecca L SkalskyVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA. skalsky@ohsu.edu.
Bryan R CullenDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. bryan.cullen@duke.edu.
Children's Cancer Therapy Development Institute · USDuke University Hospital · US

Funding

Role and mechanism of action of Gamma herpesvirus microRNAsR01AI067968 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2006 to 2016
$3.6M
The role of viral and cellular miRNAs in B-cell lymphomagenesisK99CA175181 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SKALSKY, REBECCA L · 2014 to 2015
$199k
NCI NIH HHS K99 CA175181NIAID NIH HHS R01 AI067968
6 · The paper itself

Abstract

EBV expresses a number of viral noncoding RNAs (ncRNAs) during latent infection, many of which have known regulatory functions and can post-transcriptionally regulate viral and/or cellular gene expression. With recent advances in RNA sequencing technologies, the list of identified EBV ncRNAs continues to grow. EBV-encoded RNAs (EBERs) , the BamHI-A rightward transcripts (BARTs) , a small nucleolar RNA (snoRNA) , and viral microRNAs (miRNAs) are all expressed during EBV infection in a variety of cell types and tumors. Recently, additional novel EBV ncRNAs have been identified. Viral miRNAs, in particular, have been under extensive investigation since their initial identification over ten years ago. High-throughput studies to capture miRNA targets have revealed a number of miRNA-regulated viral and cellular transcripts that tie into important biological networks. Functions for many EBV ncRNAs are still unknown; however, roles for many EBV miRNAs in latency and in tumorigenesis have begun to emerge. Ongoing mechanistic studies to elucidate the functions of EBV ncRNAs should unravel additional roles for ncRNAs in the viral life cycle. In this chapter, we will discuss our current knowledge of the types of ncRNAs expressed by EBV, their potential roles in viral latency, and their potential involvement in viral pathogenesis.

Indexed as

AnimalsEpstein-Barr Virus InfectionsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansRNA, UntranslatedRNA, ViralRNA, UntranslatedRNA, ViralBARTsEBERsmicroRNAmiRNA targetViral noncoding RNA

Identifiers

PMID26428375
PMCPMC5685189
OpenAlexW2199295618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.