ArticleInternational journal of colorectal disease2016
Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk assessment of lymph node metastasis and comparison of treatment modalities for low-risk T1b colorectal cancer: a meta-analysis.Surgical endoscopy · 2025Pooled it
- Article
- Development and explanation of a machine learning model for identifying non-localized early-onset T1 colorectal cancer.Discover oncology · 2025Article
- A novel artificial intelligence approach to the prediction of lymph node metastasis using whole-slide imaging in patients with T1 colorectal cancer.Surgical endoscopy · 2025Article
- Histological Risk Factors for Lymph Node Metastasis in pT1 Colorectal Cancer: Does Submucosal Invasion Depth Really Matter?Current medical science · 2024Article
- Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology.Virchows Archiv : an international journal of pathology · 2024Article
- Approaches and considerations in the endoscopic treatment of T1 colorectal cancer.The Korean journal of internal medicine · 2024Review
- Article
- Article
- Early Rectal Cancer and Local Excision: A Narrative Review.Journal of clinical medicine · 2024Review
- Use of artificial intelligence in the management of T1 colorectal cancer: a new tool in the arsenal or is deep learning out of its depth?Clinical endoscopy · 2024Review
- Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions.Frontiers in oncology · 2024Review
- Endoscopic resection alone as a potential treatment method for low-risk deep invasive T1 colorectal cancer.iGIE : innovation, investigation and insights · 2023Article
- Are the width, length, depth, and area of submucosal invasion predictive of lymph node metastasis in pT1 colorectal cancer?Annals of coloproctology · 2023Article
- Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series.Diagnostics (Basel, Switzerland) · 2023Article
- A proposal for grading the risk of lymph node metastasis after endoscopic resection of T1 colorectal cancer.International journal of colorectal disease · 2023Article
- An artificial intelligence prediction model outperforms conventional guidelines in predicting lymph node metastasis of T1 colorectal cancer.Frontiers in oncology · 2023Article
- Utility of artificial intelligence with deep learning of hematoxylin and eosin-stained whole slide images to predict lymph node metastasis in T1 colorectal cancer using endoscopically resected specimens; prediction of lymph node metastasis in T1 colorectal cancer.Journal of gastroenterology · 2022Article
- Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection.World journal of gastroenterology · 2022Review
- Endoscopic intermuscular dissection with intermuscular tunneling for local resection of rectal cancer with deep submucosal invasion.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2022Article
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18 authors.
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Abstract
purposeSubmucosal invasion depth (SID) in colorectal carcinoma (CRC) is an important factor in estimating risk of lymph node metastasis, but can be difficult to measure, leading to inadequate or over-extensive treatment. Here, we aimed to clarify the practical aspects of measuring SID in T1 CRC.
methodsWe investigated 568 T1 CRCs that were resected surgically at our hospital from April 2001 to December 2013, and relationships between SID and clinicopathological factors, including the means of measurement, lesion morphology, and lymph node metastasis.
resultsOf these 568 lesions, the SID was ≥1000 μm in 508 lesions. SIDs for lesions measured from the surface layer were all ≥1000 μm. Although lesions with SIDs ≥1000 μm were associated with significantly higher levels of unfavorable histologic types and lymphovascular infiltration than shallower lesions, a depth of ≥1000 μm was not a significant risk factor for lymph node metastasis (LNM) (6.7 vs. 9.8 %; P = 0.64), and no lesions for which the sole pathological factor was SID ≥1000 μm had lymph node metastasis. Protruded lesions showed deeper SIDs than other types.
conclusionsAlthough we found several problems of measuring SID in this study, we also found, surprisingly, that SID is not a risk factor for lymph node metastasis, and its measurement is not needed to estimate the risk of lymph node metastasis.
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