Evidence map›Paper›PMID 26428291›Full record

ArticleBioinformatics (Oxford, England)2016

ALP & FALP: C++ libraries for pairwise local alignment E-values.

Sergey Sheetlin, Yonil Park, Martin C Frith, John L Spouge

Open access · hybridAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Sergey SheetlinNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, MD 20894, USA and.
Yonil ParkNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, MD 20894, USA and.
Martin C FrithComputational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Koto-ku, Tokyo 135-0064, Japan.
John L SpougeNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, MD 20894, USA and.
National Institutes of Health · USNational Center for Biotechnology Information · USNational Institute of Advanced Industrial Science and Technology · JP

Funding

Mathematically Rigorous Results In Sequence Matching.ZIALM000088 · NLM · NATIONAL LIBRARY OF MEDICINE · PI SPOUGE, JOHN · 2009 to 2020
$1.7M
6 · The paper itself

Abstract

motivationPairwise local alignment is an indispensable tool for molecular biologists. In real time (i.e. in about 1 s), ALP (Ascending Ladder Program) calculates the E-values for protein-protein or DNA-DNA local alignments of random sequences, for arbitrary substitution score matrix, gap costs and letter abundances; and FALP (Frameshift Ascending Ladder Program) performs a similar task, although more slowly, for frameshifting DNA-protein alignments. AVAILABILITY AND IMPLEMENTATION: To permit other C++ programmers to implement the computational efficiencies in ALP and FALP directly within their own programs, C++ source codes are available in the public domain at http://go.usa.gov/3GTSW under 'ALP' and 'FALP', along with the standalone programs ALP and FALP. CONTACT: spouge@nih.gov SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

SoftwareComputational BiologyDatabases, FactualDNAHumansProteinsSequence AlignmentSequence Analysis, DNASequence Analysis, ProteinDNAProteins

Identifiers

PMID26428291
PMCPMC4739181
OpenAlexW2274219639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.