Evidence map›Paper›PMID 26428227›Full record

ArticleDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2015

[Impact of anastomotic leakage on long-term survival in mid-to-low rectal cancer].

T Jäger, C Nawara, D Neureiter, J Holzinger, D Öfner-Velano, A Dinnewitzer

Abstract readEnglish Abstract
PubMed Publisher
In one paragraph

Article in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. The potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

T JägerUniversitätsklinik für Chirurgie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich. ta.jaeger@salk.at.
C NawaraUniversitätsklinik für Chirurgie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich.
D NeureiterInstitut für Pathologie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich.
J HolzingerUniversitätsklinik für Chirurgie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich.
D Öfner-VelanoUniversitätsklinik für Chirurgie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich.
A DinnewitzerUniversitätsklinik für Chirurgie, Paracelsus Medizinische Privatuniversität, Salzburg, Österreich.
Paracelsus Medizinische Privatuniversität · DEInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe occurrence of anastomotic leakage (AL) after sphincter preserving anterior rectal resection in patients with rectal cancer is associated with increased morbidity and mortality. The impact of AL on long-term survival has, however, still not been sufficiently investigated and is currently the subject of controversial discussion.

objectivesThe aim of this study was to investigate the impact of AL on long-term survival in patients with Union of International Cancer Control (UICC) (y)0-III stage mid-to-low rectal cancer who underwent sphincter preserving rectal resection. MATERIAL AND

methodsA total of 108 patients with a mid-to-low rectal cancer (UICC stage (y)0-III) who underwent sphincter preserving surgery between January 2003 and October 2010 were identified within the institutional prospective colorectal cancer database. The impact of AL on 5-year overall (OS), cancer specific (CSS) and relapse-free survival (RFS) was investigated.

resultsThe overall leakage rate was 17.6 % (grade A 4.6 %, grade B 4.6 % and grade C 8.3 %). After a median follow-up of 70 months (range 24-123 months), patients with an anastomotic leakage had a significantly decreased 5-year OS (63.6 % versus 87.8 %, p = 0.02), CSS (72.2 % versus 93.5 %, p = 0.02) and RFS rate (61.1 % versus 84.2 %, p = 0.01). In univariable Cox regression analysis AL was associated with an unfavorable OS (hazard ratio HR 3.05, 95 % CI: 1.11-8.39, p = 0.03), CSS (HR 4.21, 95 % CI: 1.13-15.70, p = 0.03) and RFS (HR 3.02, 95 % CI: 1.20-7.58, p = 0.02).

conclusionIn the study cohort anastomotic leakage after sphincter preserving anterior resection in patients with mid-to-low rectal cancer was associated with a significantly unfavorable impact on overall and oncological survival.

Indexed as

AdenocarcinomaAgedAnastomotic LeakAustriaCohort StudiesDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm GradingNeoplasm StagingPostoperative ComplicationsProspective StudiesRectal NeoplasmsRisk FactorsAnastomotic leakageLong term survivalLow anterior resectionRectal cancerSphincter preservation

Identifiers

PMID26428227
OpenAlexW1795382348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.