Evidence map›Paper›PMID 26428148›Full record

ArticleCarbohydrate polymers2015

High-throughput and high-yield fabrication of uniaxially-aligned chitosan-based nanofibers by centrifugal electrospinning.

Ariane E Erickson, Dennis Edmondson, Fei-Chien Chang, Dave Wood, Alex Gong, Sheeny Lan Levengood, Miqin Zhang

Abstract read
In one paragraph

Article in Carbohydrate polymers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Fabrication of pullulan-chitosan fiber membranes for enhanced hemostatic applications.International journal of biological macromolecules · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Multi-Functional Core-Shell Nanofibers for Wound Healing.Nanomaterials (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Structural design and environmental applications of electrospun nanofibers.Composites. Part A, Applied science and manufacturing · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Anisotropic Materials for Skeletal-Muscle-Tissue Engineering.Advanced materials (Deerfield Beach, Fla.) · 2016
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ariane E EricksonDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Dennis EdmondsonDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Fei-Chien ChangDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Dave WoodDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Alex GongDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Sheeny Lan LevengoodDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Miqin ZhangDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA. Electronic address: mzhang@u.washington.edu.

Funding

Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
New 3D tumor models to rapidly test drugs for brain cancer therapyR01CA172455 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2013 to 2016
$1.1M
NCI NIH HHS NIH/NCINIH/NCI R01CA172455NCI NIH HHS R01 CA172455NCI NIH HHS T32 CA138312NCI NIH HHS T32CA138312
6 · The paper itself

Abstract

The inability to produce large quantities of nanofibers has been a primary obstacle in advancement and commercialization of electrospinning technologies, especially when aligned nanofibers are desired. Here, we present a high-throughput centrifugal electrospinning (HTP-CES) system capable of producing a large number of highly-aligned nanofiber samples with high-yield and tunable diameters. The versatility of the design was revealed when bead-less nanofibers were produced from copolymer chitosan/polycaprolactone (C-PCL) solutions despite variations in polymer blend composition or spinneret needle gauge. Compared to conventional electrospinning techniques, fibers spun with the HTP-CES not only exhibited superior alignment, but also better diameter uniformity. Nanofiber alignment was quantified using Fast Fourier Transform (FFT) analysis. In addition, a concave correlation between the needle diameter and resultant fiber diameter was identified. This system can be easily scaled up for industrial production of highly-aligned nanofibers with tunable diameters that can potentially meet the requirements for various engineering and biomedical applications.

Indexed as

ElectricityCentrifugationChitosanNanofibersNanotechnologyNeedlesChitosanAlignmentCentrifugal electrospinningHigh-throughputNanofibers

Identifiers

PMID26428148
PMCPMC4855845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.