ArticleAngewandte Chemie (International ed. in English)2015
A Eu(II)-Containing Cryptate as a Redox Sensor in Magnetic Resonance Imaging of Living Tissue.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Cyclen Tetra-Amide Ligands as a Privileged Class of Ligands for Studying Second-Sphere Coordination Environments.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Single Molecule EuJournal of the American Chemical Society · 2026Article
- Controlling the Kinetic and Electrochemical Properties of EuInorganic chemistry · 2026Article
- Solution-Phase Electrochemical Characterization of Acyclic Complexes of Divalent Europium.Inorganic chemistry · 2026Article
- Reversible Enzymatic Switching of the Oxidation State of a EuJournal of the American Chemical Society · 2025Article
- Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025Article
- Divalent Intermediates in Lanthanide-Based Photocatalysts: Spectroscopic Characterization and Reactivity.Inorganic chemistry · 2025Article
- Expanding the Coordination of f-Block Metals with Tris[2-(2-methoxyethoxy)ethyl]amine: From Molecular Complexes to Cage-like Structures.Inorganic chemistry · 2024Article
- Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia.Advanced healthcare materials · 2023Article
- An Fe complex forChemical science · 2023Article
- Toward quantification of hypoxia using fluorinated EuProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia.Journal of the American Chemical Society · 2022Article
- Solid-state and solution-phase characterization of SmDalton transactions (Cambridge, England : 2003) · 2022Article
- Rational Design of High-Relaxivity EuChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Rational Ligand Design Enables pH Control over Aqueous Iron Magnetostructural Dynamics and Relaxometric Properties.Inorganic chemistry · 2020Article
- Measurement of the Dissociation of EuInorganic chemistry · 2020Article
- Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.Journal of the American Chemical Society · 2019Review
- Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex.Journal of the American Chemical Society · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Screening of ligands for redox-active europium using magnetic resonance imaging.Bioorganic & medicinal chemistry · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The Eu(II) ion rivals Gd(III) in its ability to enhance contrast in magnetic resonance imaging. However, all reported Eu(II)-based complexes have been studied in vitro largely because the tendency of Eu(II) to oxidize to Eu(III) has been viewed as a major obstacle to in vivo imaging. Herein, we present solid- and solution-phase characterization of a Eu(II)-containing cryptate and the first in vivo use of Eu(II) to provide contrast enhancement. The results indicate that between one and two water molecules are coordinated to the Eu(II) core upon dissolution. We also demonstrate that Eu(II)-based contrast enhancement can be observed for hours in a mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.