Evidence map›Paper›PMID 26427919›Full record

ArticleHospital pediatrics2015

Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.

Stephen W Patrick, James F Burke, Terry J Biel, Katherine A Auger, Neera K Goyal, William O Cooper

Open access · greenAbstract read
In one paragraph

Article in Hospital pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
11.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. Pediatric Primary Care Diagnoses Among Children with Intrauterine Opioid Exposure.Journal of health care for the poor and underserved · 2023
    Article
  12. Article
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  15. Growth failure in infants with neonatal abstinence syndrome in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Stephen W PatrickDepartments of Pediatrics, and Mildred Stahlman Division of Neonatology, Vanderbilt University, Nashville, Tennessee; Vanderbilt Center for Health Services Research, Nashville, Tennessee; Health Policy, and stephen.patrick@vanderbilt.edu.
James F BurkeDepartment of Neurology, and.
Terry J BielSchool of Medicine, University of Michigan, Ann Arbor, Michigan; and.
Katherine A AugerDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio.
Neera K GoyalDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio.
William O CooperDepartments of Pediatrics, and Vanderbilt Center for Health Services Research, Nashville, Tennessee; Health Policy, and.
University of Cincinnati · USVanderbilt Health · USUniversity of Michigan–Ann Arbor · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)KL2TR000446 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$2.8M
Using Outcomes Analyses to Inform Implementation of NINDS Clinical TrialsK08NS082597 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURKE, JAMES FRANCIS · 2013 to 2017
$948k
Neonatal Abstinence Syndrome: Risk of Drug Withdrawal in Opioid-Exposed InfantsK23DA038720 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATRICK, STEPHEN W · 2015 to 2019
$844k
NCATS NIH HHS KL2 TR000446NCATS NIH HHS KL2TR000446NIDA NIH HHS 1K23DA038720-01NIDA NIH HHS K23 DA038720NINDS NIH HHS K08 NS082597
6 · The paper itself

Abstract

objectiveNeonatal abstinence syndrome (NAS) is a postnatal drug withdrawal syndrome that may last for months. Our objective was to determine if infants with NAS are at increased risk for hospital readmission compared with uncomplicated term and late preterm newborns.

methodsIn this longitudinal retrospective cohort study, administrative data were used for all births from 2006 to 2009 in the New York State Inpatient Database. We identified infants with NAS, born late preterm or uncomplicated term, as independent groups using diagnostic codes and determined readmission rates. We fit a multivariable logistic regression model with 30-day readmission after discharge as the outcome and infant characteristics, clinical morbidities, insurance type, and length of birth hospitalization as predictors.

resultsFrom 2006 to 2009 in New York State, 700 613 infants were classified as uncomplicated term, 51 748 were born late preterm, and 1643 infants were diagnosed with NAS. After adjusting for confounders, infants with NAS (odds ratio [OR] 2.49, 95% confidence interval [CI] 1.75-3.55) were more likely than uncomplicated term infants to be readmitted within 30 days of birth hospitalizations. The risk of readmission was similar to late preterm infants (OR 2.26, 95% CI 2.09-2.45). Length of birth hospitalization in days was inversely related to odds of being readmitted within 30 days of birth hospitalization (OR 0.94 95% CI 0.92-0.96).

conclusionsWhen compared with uncomplicated term infants, infants diagnosed with NAS were more than twice as likely to be readmitted to the hospital. Future research and state-level policies should investigate means to mitigate risk of hospital readmission for infants with NAS.

Indexed as

FemaleHumansInfantInfant, NewbornLength of StayMaleMultivariate AnalysisNeonatal Abstinence SyndromePatient ReadmissionRetrospective Studies

Identifiers

PMID26427919
PMCPMC5110214
OpenAlexW2343977067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.