Evidence map›Paper›PMID 26427917›Full record

ArticleSchizophrenia research2015

Improving the understanding of the link between cognition and functional capacity in schizophrenia and bipolar disorder.

Raeanne C Moore, Alexandrea L Harmell, Philip D Harvey, Christopher R Bowie, Colin A Depp, Ann E Pulver, John A McGrath, Thomas L Patterson, Veronica Cardenas, Paula Wolyniec and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Pooled it
  4. Review
  5. Article
  6. Review
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  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raeanne C MooreDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States. Electronic address: r6moore@ucsd.edu.
Alexandrea L HarmellDepartment of Psychiatry, University of California, San Diego, United States; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States. Electronic address: aharmell@ucsd.edu.
Philip D HarveyUniversity of Miami Miller School of Medicine, United States. Electronic address: pharvey@med.miami.edu.
Christopher R BowieDepartment of Psychology, Queen's University, Ontario, Canada. Electronic address: bowiec@queensu.ca.
Colin A DeppDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States; VA San Diego Healthcare System, San Diego, CA, United States. Electronic address: cdepp@ucsd.edu.
Ann E PulverDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: aepulver@jhmi.edu.
John A McGrathDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: jmcgrath@jhmi.edu.
Thomas L PattersonDepartment of Psychiatry, University of California, San Diego, United States. Electronic address: tpatterson@ucsd.edu.
Veronica CardenasDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States. Electronic address: vcardenas@ucsd.edu.
Paula WolyniecDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: wolyniec@jhmi.edu.
Mary H ThornquistDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: thornquist@jhmi.edu.
James R LukeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: jrluke@jhmi.edu.
Barton W PalmerDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States. Electronic address: bpalmer@ucsd.edu.
Dilip V JesteDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States. Electronic address: djeste@ucsd.edu.
Brent T MausbachDepartment of Psychiatry, University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, United States. Electronic address: bmausbach@ucsd.edu.

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
CORE--RESEARCH NETWORK DEVELOPMENT COREP30MH066248 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JESTE, DILIP V. · 2002 to 2006
$7.4M
Chronic Psychiatric Disorders: Linking Genes to Functional DisabilityR01MH079784 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PULVER, ANN E · 2007 to 2011
$3.8M
Skills Training and Empowerment Program for Middle-Aged and Older Patients with PR01MH084967 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAUSBACH, BRENT T · 2009 to 2013
$2.8M
Real-Time Mobile Cognitive Behavioral Intervention for Serious Mental IllnessR01MH100417 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2013 to 2016
$2.1M
Real-Time Mobile Assessment of Daily Functioning Among Older HIV-Infected AdultsK23MH107260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2015 to 2018
$927k
NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIMH NIH HHS K23 MH107260NIMH NIH HHS L30 MH104725NIMH NIH HHS P30 MH066248NIMH NIH HHS P30MH066248NIMH NIH HHS R01MH070784NIMH NIH HHS R01 MH079784NIMH NIH HHS R01 MH084967NIMH NIH HHS R01MH084967NIMH NIH HHS R01 MH100417NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

objectiveDeficits in cognitive functioning are related to functional disability in people with serious mental illness. Measures of functional capacity are commonly used as a proxy for functional disabilities for cognitive remediation programs, and robust linear relationships between functional capacity and cognitive deficits are frequently observed. This study aimed to determine whether a curvilinear relationship better approximates the association between cognitive functioning and functional capacity.

methodTwo independent samples were studied. Study 1: participants with schizophrenia (n=435) and bipolar disorder (n=390) aged 18-83 completed a neuropsychological battery and a performance-based measure of functional capacity. Study 2: 205 participants with schizophrenia (age range=39-72) completed a brief neuropsychological screening battery and a performance-based measure of functional capacity. For both studies, linear and quadratic curve estimations were conducted with cognitive performance predicting functional capacity scores.

resultsSignificant linear and quadratic trends were observed for both studies. Study 1: in both the schizophrenia and bipolar participants, when cognitive composite z-scores were >0 (indicating normal to above normal performance), cognition was not related to functional capacity. Study 2: when neuropsychological screening battery z-scores were >-1 (indicating low average to average performance), cognition was not related to functional capacity.

conclusionsThese results illustrate that in cognitively normal adults with serious mental illness, the relationship between cognitive function and functional capacity is relatively weak. These findings may aid clinicians and researchers determine who may optimally benefit from cognitive remediation programs, with greater benefits possibly being achieved for individuals with cognitive deficits relative to individuals with normal cognition.

Indexed as

CognitionSchizophreniaSchizophrenic PsychologyActivities of Daily LivingAdolescentAdultAgedAged, 80 and overBipolar DisorderFemaleHumansLinear ModelsMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesCognitive remediationDisabilityFunctional capacityFunctioningNeuropsychological assessmentSerious mental illness

Identifiers

PMID26427917
PMCPMC4681671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.