Evidence map›Paper›PMID 26427904›Full record

ReviewExpert review of cardiovascular therapy2015

Orthostatic hypotension: managing a difficult problem.

Pearl K Jones, Brett H Shaw, Satish R Raj

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of cardiovascular therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Dysautonomia: A Forgotten Condition - Part II.Arquivos brasileiros de cardiologia · 2021
    Article
  6. Dyspnea in Chronic Low Ventricular Preload States.Annals of the American Thoracic Society · 2021
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. (r)Alpha Lipoic Acid Is a Safe, Effective Pharmacologic Therapy of Chronic Orthostatic Hypotension Associated with Low Sympathetic Tone.The International journal of angiology : official publication of the International College of Angiology, Inc · 2019
    Article
  13. Syncope and Headache.Current pain and headache reports · 2018
    Review
  14. Review
  15. Article
  16. Editorial: Autonomic Neuropathy and Cardiovascular Disease in Aging.The journal of nutrition, health & aging · 2018
    Article
  17. Orthostatic hypotension for the cardiologist.Current opinion in cardiology · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Pearl K Jonesa 1 Department of Neurology, University of Texas Health Sciences Center, San Antonio, TX, USA.
Brett H Shawb 2 Department of Cardiac Science, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Satish R Rajb 2 Department of Cardiac Science, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Libin Cardiovascular Institute of Alberta · CAThe University of Texas Health Science Center at San Antonio · USVanderbilt University · US

Funding

Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
Aldosterone and Sodium Regulation in Postural Tachycardia SyndromeR01HL102387 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GARLAND, EMILY M · 2010 to 2014
$2.1M
NHLBI NIH HHS P01 HL056693NHLBI NIH HHS R01 HL102387
6 · The paper itself

Abstract

Orthostatic hypotension (OH) leads to a significant number of hospitalizations each year, and is associated with significant morbidity and mortality among affected individuals. Given the increased risk for cardiovascular events and falls, it is important to identify the underlying etiology of OH and to choose appropriate therapeutic agents. OH can be non-neurogenic or neurogenic (arising from a central or peripheral lesion). The initial evaluation includes orthostatic vital signs, complete history and a physical examination. Patients should also be evaluated for concomitant symptoms of post-prandial hypotension and supine hypertension. Non-pharmacologic interventions are the first step for treatment of OH. The appropriate selection of medications can also help with symptomatic relief. This review highlights the pathophysiology, clinical features, diagnostic work-up and treatment of patients with neurogenic OH.

Indexed as

HumansHypertensionHypotension, Orthostaticautonomic failureautonomic nervous systemdroxidopamultiple system atrophyorthostatic hypotensionorthostatic intoleranceParkinson’s diseaseperipheral neuropathy

Identifiers

PMID26427904
PMCPMC4883667
OpenAlexW1825491284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.