ArticleAJNR. American journal of neuroradiology2016
Spine Cryoablation: Pain Palliation and Local Tumor Control for Vertebral Metastases.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02838758 (A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma), which is not on this map. Cited by 60 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma
Who cites it
60 citing papers in PubMed, 8 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Percutaneous cryoablation in the management of spinal metastases: a comprehensive systematic review and meta-analysis.Journal of neuro-oncology · 2025Pooled it
- Image-guided cryoablation for palliation of painful bone metastases: a systematic review and meta-analysis.Skeletal radiology · 2025Pooled it
- The role of minimally invasive surgery within a multidisciplinary approach for patients with metastatic spine disease over a decade: A systematic review.Neuro-oncology · 2024Pooled it
- Magnetic resonance-guided focused ultrasound versus percutaneous thermal ablation in local control of bone oligometastases: a systematic review and meta-analysis.La Radiologia medica · 2024Pooled it
- Cryoablation for the Palliation of Painful Bone Metastasis: A Systematic Review.Cardiovascular and interventional radiology · 2023Pooled it
- Treatment progress of spinal metastatic cancer: a powerful tool for improving the quality of life of the patients.Journal of orthopaedic surgery and research · 2023Pooled it
- Thermal ablation to relieve pain from metastatic bone disease: a systematic review.Skeletal radiology · 2019Pooled it
- Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR).La Radiologia medica · 2019Guideline
- Interventional Radiology in the Treatment of Musculoskeletal Tumours.Current oncology (Toronto, Ont.) · 2026Review
- Clinical efficacy and safety of robot-assisted targeted co-ablation combined with vertebroplasty under local anesthesia for spinal metastases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Co-Ablation System for Pain Management in Bone Metastases: Retrospective Exploratory Study.JMIR cancer · 2026Article
- Trends and hotspots in the studies of spinal metastasis: A bibliometric analysis from 2000 to 2023.Medicine · 2026Review
- Spinal cord protection by epidural separation during vertebral cryoablation for metastatic spine disease: A proof-of-concept preclinical study.Brain & spine · 2026Article
- Impact of Neurorehabilitation on Functional Recovery in patients with Intradural Spinal Cord Tumors: A retrospective analysis in a resource-limited setting.Pakistan journal of medical sciences · 2025Article
- Radiofrequency Ablation and Cryoablation in Treating Painful Bone Metastasis: A Comprehensive Systematic Review and Separate Single-Arm Meta-analysis.Orthopedic reviews · 2025Article
- Review
- Evaluation of Conditions for the Development of Cryogenic Spinal Cord Injury Using a Canine Model: An Experimental Study on the Safety of Cryoablation for Metastatic Spinal Tumors.AJNR. American journal of neuroradiology · 2024Article
- Percutaneous Vertebral Augmentation and Thermal Ablation in Patients with Spinal Metastases.Seminars in interventional radiology · 2024Review
- CT-Guided Microwave Ablation with Vertebral Augmentation for Spinal Metastases with Posterior Wall Defects.Journal of pain research · 2024Article
- Spine metastases: thermal ablation and augmentation.Skeletal radiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePercutaneous cryoablation has emerged as a minimally invasive technique for the management of osseous metastases. The purpose of this study was to assess the safety and effectiveness of percutaneous imaging-guided spine cryoablation for pain palliation and local tumor control for vertebral metastases. MATERIALS AND
methodsImaging-guided spine cryoablation was performed in 14 patients (31 tumors) with vertebral metastases refractory to conventional chemoradiation therapy or analgesics, to achieve pain palliation and local tumor control in this retrospective study. Spinal nerve and soft-tissue thermal protection techniques were implemented in all ablations. Patient response was evaluated by a pain numeric rating scale administered before the procedure and 1 week, 1 month, and 3 months after the procedure. Pre- and postprocedural analgesic requirements (expressed as morphine-equivalent dosages) were also analyzed at the same time points. Pre- and postprocedural cross-sectional imaging was evaluated in all patients to assess local control (no radiographic evidence of disease at the treated sites). Complications were monitored. Analysis of the primary end points was undertaken via paired-comparison procedures by using the Wilcoxon signed rank test.
resultsThirty-one tumors were ablated in 14 patients (9 women and 5 men; 20-73 years of age; mean age, 53 years). The most common tumor location was in the lumbar spine (n = 14, 45%), followed by the thoracic spine (n = 8, 26%), sacrum (n = 6, 19%), coccyx (n = 2, 6%), and cervical spine (n = 1, 3%). There were statistically significant decreases in the median numeric rating scale score and analgesic usage at 1-week, 1-month, and 3-month time points (P < .001 for all). Local tumor control was achieved in 96.7% (30/31) of tumors (median follow-up, 10 months). Two patients had transient postprocedural unilateral lower extremity radiculopathy and weakness.
conclusionsPercutaneous imaging-guided spine cryoablation is a safe and effective treatment for pain palliation and local tumor control for vertebral metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.