ArticleEuropean radiology2016
Protective effect against repeat adverse reactions to iodinated contrast medium: Premedication vs. changing the contrast medium.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Hypersensitivity reactions to contrast media: Part 2. Prevention of recurrent hypersensitivity reactions in adults. Updated guidelines by the ESUR Contrast Media Safety Committee.European radiology · 2025Guideline
- Substituting with alternative iodinated contrast medium to prevent recurrent adverse drug reactions associated with its use: a meta-analysis.European radiology · 2025Pooled it
- Pooled it
- Superselective intra-arterial infusion of cisplatin and concomitant radiation therapy (RADPLAT) using gadolinium-based contrast agent in a patient with severe iodine allergy: A case report.Radiology case reports · 2026Article
- Case Report: Zero-contrast multivessel PCI with left main bifurcation guided by dual IVUS strategies using a coronary CTA roadmap.Frontiers in cardiovascular medicine · 2026Article
- Risk factor analysis of iodinated contrast medium-related hypersensitivity reactions.Insights into imaging · 2025Review
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- Are gadolinium-based contrast media safe alternatives to iodinated contrast agents for the safe performance of spinal injection procedures?Interventional pain medicine · 2025Article
- Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management.Frontiers in medicine · 2025Review
- Contrast-induced posterior reversible encephalopathy syndrome following diagnostic angiography of vertebral artery.Surgical neurology international · 2025Article
- N-(2,3-dihydroxypropyl) carbamoyl side chain: a potentially significant factor for recurrent iodinated contrast medium-related adverse drug reactions.European radiology · 2024Article
- Successful Embolization of a Direct Carotid Cavernous Fistula under Gadolinium-Based Angiography.Neurointervention · 2024Article
- Immediate hypersensitivity reactions to iodinated contrast media despite drug prophylaxis-a comparative retrospective cohort study of breakthrough reactions in Bern (Switzerland) and Seoul (South Korea).Quantitative imaging in medicine and surgery · 2024Article
- Stratified assessment and warning regimen for prevention of acute adverse reactions to iodinated contrast media: results of 150,343 cases in a tertiary hospital.Medical & biological engineering & computing · 2023Article
- Indian College of Radiology and Imaging Consensus Guidelines on Interventions in Pancreatitis.The Indian journal of radiology & imaging · 2022Review
- Pharmacological Prevention of Hypersensitivity Reactions Caused by Iodinated Contrast Media: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- To crack a nut with a sledgehammer: premedication in a patient with a history of mild symptoms following the injection of a contrast agent.Quantitative imaging in medicine and surgery · 2022Article
- Diagnosis and Prevention of Hypersensitivity Reactions to Iodinated Contrast Media.Allergy, asthma & immunology research · 2022Review
- Hypersensitivity Reactions to Iodinated Contrast Media.Biomedicines · 2022Review
- Contrast Medium Hypersensitivity: A Large Italian Study with Long-Term Follow-Up.Biomedicines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to assess the protective effect of premedication and changing contrast media (CM) against repeat adverse reactions (ARs) to iodinated CM.
methodsBetween January 2006 and September 2014, 771 cases with previous ARs to CM were administered CM. The same CM that had caused ARs previously was administered to 491 cases (220 without premedication [defined as the control group], and 271 with premedication [the premedication alone group]). A different CM from the previous CM was given to 280 cases (58 without premedication [the changing CM alone group], and 222 with premedication [the premedication and changing CM group]).
resultsThe control group had 61 repeat ARs (27.7%). The premedication alone group had 47 ARs (17.3%, p<0.01). The changing CM alone group had 3 ARs (5.2%, p<0.001). Three ARs (7.9%) were observed in 38 cases changing from one to another low-osmolar nonionic CM. Twenty cases with previous ARs to the high-osmolar CM and to the low-osmolar ionic CM showed no ARs. The premedication and changing CM group had 6 ARs (2.7%, p<0.001).
conclusionPremedication prior to contrast for patients with previous ARs may be protective, however, changing CM was more effective. KEY POINTS: • In patients with previous adverse reactions, changing contrast media is recommended. • Premedication is unnecessary against previous reactions to high-osmolar or ionic CM. • Changing from one to another low-osmolar non-ionic CM may be effective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.