ArticleNeuroImage2016
Generative models of the human connectome.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.
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Who cites it
154 citing papers in PubMed.
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- Geometric constraints and cognitive inputs jointly shape emergent brain dynamics and topology.bioRxiv : the preprint server for biology · 2026Article
- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Spatial connectivity for local cortical homogeneity.Research square · 2026Article
- Whole-brain cellular-resolution functional network properties of seizure susceptibility.bioRxiv : the preprint server for biology · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Analytically tractable model of synaptic crowding explains emergent small-world structure and network dynamics.Scientific reports · 2026Article
- Evolutionary Kuramoto dynamics unravels origins of chimera states in neural populations.PLoS computational biology · 2026Article
- Sensitivity analysis enlightens effects of connectivity in a Neural Mass Model under Control-Target mode.PLoS computational biology · 2026Article
- Multiscale connectivity framework for working memory network in paediatric acute lymphoblastic leukaemia survivors.Brain communications · 2026Article
- Human cortical dynamics reflect graded contributions of local geometry and network topography.Nature communications · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Unifying equivalences across unsupervised learning, network science, and imaging/network neuroscience.ArXiv · 2025Article
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- Exploring the transmission of cognitive task information through optimal brain pathways.PLoS computational biology · 2025Article
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- Brain wiring economics, network organisation and population-level genomics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025Article
94 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
Abstract
The human connectome represents a network map of the brain's wiring diagram and the pattern into which its connections are organized is thought to play an important role in cognitive function. The generative rules that shape the topology of the human connectome remain incompletely understood. Earlier work in model organisms has suggested that wiring rules based on geometric relationships (distance) can account for many but likely not all topological features. Here we systematically explore a family of generative models of the human connectome that yield synthetic networks designed according to different wiring rules combining geometric and a broad range of topological factors. We find that a combination of geometric constraints with a homophilic attachment mechanism can create synthetic networks that closely match many topological characteristics of individual human connectomes, including features that were not included in the optimization of the generative model itself. We use these models to investigate a lifespan dataset and show that, with age, the model parameters undergo progressive changes, suggesting a rebalancing of the generative factors underlying the connectome across the lifespan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.