Evidence map›Paper›PMID 26427563›Full record

Trial reportContemporary clinical trials2015

Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion.

Sheri J Hartman, Loki Natarajan, Barton W Palmer, Barbara Parker, Ruth E Patterson, Dorothy D Sears

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sheri J HartmanDepartment of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA. Electronic address: sjhartman@ucsd.edu.
Loki NatarajanDepartment of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Barton W PalmerDepartment of Psychiatry, UC San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Barbara ParkerUC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Ruth E PattersonDepartment of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Dorothy D SearsDepartment of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA; Department of Medicine, UC San Diego, La Jolla, CA, USA.
Moores Cancer CenterUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

Physical Activity and neuropsychological outcomes in a cancer populationK07CA181323 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HARTMAN, SHERI J · 2014 to 2018
$852k
NCI NIH HHS K07 CA181323NCI NIH HHS K07CA181323
6 · The paper itself

Abstract

introductionMany breast cancer survivors experience problems with cognitive functioning that can persist years after treatment. Increasing physical activity has been shown to improve cognitive functioning in healthy and cognitively impaired adults, but has not yet been tested in cancer survivors. The primary aim of this randomized controlled trial is to examine the effects of a 3-month physical activity intervention compared to a waitlist Control arm on neuropsychological outcomes and subjective cognitive concerns in breast cancer survivors.

methodsEighty sedentary breast cancer survivors, self-reporting difficulties with cognition, will be randomized into an Exercise arm or Control arm. The Exercise arm includes an activity tracker (i.e., a Fitbit), phone calls, plus tailored and non-tailored email content. The Control arm will receive emails on women's health topics on the same schedule as the Exercise arm. Assessments conducted at baseline and 3 months include: neuropsychological testing, cognitive concerns and other aspects of quality of life, and 7 days of a hip-worn accelerometer. Participants will also provide fasting blood draws to assess brain-derived neurotropic factor, Insulin-like growth factor 1, insulin resistance, and C-reactive protein. Primary and secondary outcomes are changes in neuropsychological testing and cognitive concerns. Biomarkers will be examined to further understand the underlying relationship between physical activity and cognition.

conclusionThe Memory & Motion study is designed to test whether increasing physical activity can improve cognitive functioning in breast cancer survivors. Results from this study could be used to guide development of interventions to improve cognitive functioning in breast cancer survivors.

Indexed as

ExerciseAccelerometryBiomarkersBrain-Derived Neurotrophic FactorBreast NeoplasmsCognition DisordersC-Reactive ProteinFemaleHumansInsulin-Like Growth Factor IMemoryMental HealthPatient CompliancePhysical FitnessQuality of LifeResearch DesignBiomarkersBrain-Derived Neurotrophic FactorC-Reactive ProteinInsulin-Like Growth Factor IBreast cancerCognitive functioningPhysical activityRandomized controlled trial

Identifiers

PMID26427563
PMCPMC4674350
OpenAlexW1853032990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.