ArticleMethods (San Diego, Calif.)2016
Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells.
Article in Methods (San Diego, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Real-Time Biophysical Phenotyping and Sorting of Transiting Cells Along a Constriction Microchannel.Micromachines · 2026Article
- BRAF Modulates the Interplay Between Cell-Cell and Cell-Extracellular Matrix Adhesions in PECAM-1-Mediated Mechanotransduction.International journal of molecular sciences · 2024Article
- Nuclear envelope mechanobiology: linking the nuclear structure and function.Nucleus (Austin, Tex.) · 2021Review
- Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing.Nature communications · 2021Article
- Ankyrin G organizes membrane components to promote coupling of cell mechanics and glucose uptake.Nature cell biology · 2021Article
- The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex.The Journal of biological chemistry · 2020Article
- Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.Development (Cambridge, England) · 2020Article
- Mechanical Characterization for Cellular Mechanobiology: Current Trends and Future Prospects.Frontiers in bioengineering and biotechnology · 2020Review
- The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress.The Journal of biological chemistry · 2019Article
- Fluid forces shape the embryonic heart: Insights from zebrafish.Current topics in developmental biology · 2019Review
- SHP-2 is activated in response to force on E-cadherin and dephosphorylates vinculin Y822.Journal of cell science · 2018Article
- Mechanotransduction in tumor progression: The dark side of the force.The Journal of cell biology · 2018Review
- Biomechanical Characterization at the Cell Scale: Present and Prospects.Frontiers in physiology · 2018Review
- Advanced and Rationalized Atomic Force Microscopy Analysis Unveils Specific Properties of Controlled Cell Mechanics.Frontiers in physiology · 2018Article
- Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.Nature cell biology · 2017Article
- Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cellular tension has implications in normal biology and pathology. Membrane adhesion receptors serve as conduits for mechanotransduction that lead to cellular responses. Ligand-conjugated magnetic beads are a useful tool in the study of how cells sense and respond to tension. Here we detail methods for their use in applying tension to cells and strategies for analyzing the results. We demonstrate the methods by analyzing mechanotransduction through VE-cadherin on endothelial cells using both permanent magnets and magnetic tweezers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.