Evidence map›Paper›PMID 26427409›Full record

ArticleAdvances in experimental medicine and biology2016

A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.

Jeremy R Charette, Ivy S Samuels, Minzhong Yu, Lisa Stone, Wanda Hicks, Lan Ying Shi, Mark P Krebs, Jürgen K Naggert, Patsy M Nishina, Neal S Peachey

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A New Mouse Model for Complete Congenital Stationary Night Blindness Due toInternational journal of molecular sciences · 2021
    Article
  5. Review
  6. Article
  7. Reduced expression of theMolecular vision · 2019
    Article
  8. Article
  9. Article
  10. Noninvasive Prenatal Diagnosis Significance of ERG Methylation as a Biomarker in Down's Syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  11. Article
  12. A mutagenesis-derivedMolecular vision · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeremy R CharetteThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Jeremy.Charette@jax.org.
Ivy S SamuelsLouis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. Ivy.Samuels@va.gov.
Minzhong YuCole Eye Institute, Cleveland Clinic, 44195, Cleveland, OH, USA. YUM@ccf.org.
Lisa StoneThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Lisa.Stone@jax.org.
Wanda HicksThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Wanda.jordan@jax.org.
Lan Ying ShiThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. lanying_shi1234@163.com.
Mark P KrebsThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Mark.Krebs@jax.org.
Jürgen K NaggertThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Juergen.Naggert@jax.org.
Patsy M NishinaThe Jackson Laboratory, 04609, Bar Harbor, ME, USA. Nishina@jax.org.
Neal S PeacheyLouis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. peachen@ccf.org.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Models for Vision ResearchR01EY016501 · NEI · JACKSON LABORATORY · PI NISHINA, PATSY M · 2005 to 2014
$9.4M
BLRD VA IK6 BX005233NCI NIH HHS P30 CA034196NCI NIH HHS P30CA34196NEI NIH HHS R01 EY016501NEI NIH HHS R01EY16501
6 · The paper itself

Abstract

Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.

Indexed as

MutationAllelesAnimalsDisease Models, AnimalElectroretinographyEye DiseasesGenetic Predisposition to DiseaseGenetic TestingG-Protein-Coupled Receptor Kinase 1HumansMaleMembrane ProteinsMice, Inbred C57BLMice, Inbred DBAMutagenesisReceptors, Metabotropic GlutamateG-Protein-Coupled Receptor Kinase 1Grk1 protein, mouseLrit3 protein, mouseMembrane Proteinsmetabotropic glutamate receptor type 1Receptors, Metabotropic GlutamateElectroretinogramMiceMutagenesisPhotoreceptorRetina

Identifiers

PMID26427409
PMCPMC6716159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.