SynthesisPLoS genetics2015
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 246 papers, 19 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 19 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
246 citing papers in PubMed, 19 syntheses or guidelines pooled it.
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank.Nature communications · 2025Pooled it
- Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.Biology of sex differences · 2024Pooled it
- GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005) · 2023Pooled it
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.Nature genetics · 2022Pooled it
- Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.Communications biology · 2022Pooled it
- Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals.Arteriosclerosis, thrombosis, and vascular biology · 2022Pooled it
- Large-scale association study on daily weight gain in pigs reveals overlap of genetic factors for growth in humans.BMC genomics · 2022Pooled it
- Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.Evolution; international journal of organic evolution · 2021Pooled it
- The association between polymorphisms near TMEM18 and the risk of obesity: a meta-analysis.BMC medical genomics · 2021Pooled it
- Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.PLoS genetics · 2021Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.Nature communications · 2020Pooled it
- Genome-wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls.Translational psychiatry · 2020Pooled it
- Identification of a 1p21 independent functional variant for abdominal obesity.International journal of obesity (2005) · 2019Pooled it
- Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.American journal of epidemiology · 2019Pooled it
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.Nature genetics · 2019Pooled it
- Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.International journal of obesity (2005) · 2018Pooled it
- Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy.Open forum infectious diseases · 2025Trial
186 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
445 authors.
Thomas W WinklerDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Llilda BarataDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Su ChuCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Jacek CzajkowskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Tõnu EskoBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Tove FallScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Reedik MägiEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Evelin MihailovEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Tune H PersDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Sina RüegerSwiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Georg B EhretDepartment of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Teresa FerreiraWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Nancy L Heard-CostaDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America.
Juha KarjalainenUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Vasiliki LagouWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Michael D NeinastDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Hammersmith Hospital, London, United Kingdom; Department of Genomics of Common Diseases, School of Public Health, Imperial College London, London, United Kingdom.
Jeannette SiminoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Tanya M TeslovichCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Rick JansenDepartment of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Harm-Jan WestraProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America.
Charles C WhiteDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.
Tarunveer S AhluwaliaNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center A/S, Gentofte, Denmark; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Shafqat AhmadDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.
Jennifer L Bragg-GreshamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Joshua C BisCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Amélie BonnefondCNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Gabrielle BoucherMontreal Heart Institute, Montréal, Québec, Canada.
Gemma CadbyCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
Yu-Ching ChengVA Maryland Health Care System, Baltimore, Maryland, United States of America; University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America.
Charleston W K ChiangDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.
Graciela DelgadoVth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Nicole DuekerUniversiy of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America.
Niina EklundNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Joel ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Krista FischerEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Francesca FrauDepartment of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy.
Tessel E GaleslootRadboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Tanja B GrammerVth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Stefan GustafssonScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Saskia HaitjemaExperimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jennifer E HuffmanNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Kevin B JacobsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America.
Åsa JohanssonScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Marika KaakinenDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom; Institute of Health Sciences, University of Oulu, Oulu, Finland.
Marcus E KleberVth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Jari LahtiFolkhälsan Research Centre, Helsinki, Finland; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Irene Mateo LeachUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Youfang LiuThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America.
Ken Sin LoMontreal Heart Institute, Montréal, Québec, Canada.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Pamela A F MaddenWashington University Medical School, St. Louis, Missouri, United States of America.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Barbara McKnightCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Carolina Medina-GomezNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Keri L MondaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; The Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of America.
May E MontasserProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Gabriele MüllerCenter for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany.
Ilja M NolteUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Kalliope PanoutsopoulouWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Laura PascoeInstitute of Cell & Molecular Biosciences, Newcastle University, Newcastle, United Kingdom.
Lavinia PaternosterMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Nigel W RaynerWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Federica RizziDepartment of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Kathy A RyanProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Perttu SaloNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland.
Serena SannaIstituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Jianxin ShiNational Cancer Institute, Bethesda, Maryland, United States of America.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Lorraine SouthamWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Valgerdur SteinthorsdottirdeCODE Genetics, Amgen inc., Reykjavik, Iceland.
Rona J StrawbridgeAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ioanna TachmazidouWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Gudmar ThorleifssondeCODE Genetics, Amgen inc., Reykjavik, Iceland.
Stella TrompetDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Natalia PervjakovaEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute of Cell and Molecular Biology, Department of Biotechnology, University of Tartu, Tartu, Estonia; University of Helsinki, Helsinki, Finland.
Jonathan P TyrerDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sander W van der LaanExperimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Nathalie van der VeldeDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Jessica van SettenDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands.
Jana V van Vliet-OstaptchoukUniversity of Groningen, University Medical Center Groningen, Department of Endocrinology, Groningen, The Netherlands.
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Efthymia VlachopoulouTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.
Sophie R WangDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, United States of America; Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts, United States of America.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America.
Sarah H WildCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Christina WillenborgDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
James F WilsonCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Andrew WongMRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Jian YangQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Loïc YengoCNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Laura M Yerges-ArmstrongProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom.
Jing Hua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Ehm A AnderssonNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stephan J L BakkerUniversity of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands.
Damiano BaldassarreCentro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Karina BanasikNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Matteo BarcellaDepartment of Health Sciences, University of Milan, Milan, Italy.
Cristina BarlassinaDepartment of Health Sciences, University of Milan, Milan, Italy.
Claire BellisDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Paola BenaglioDepartment of Pediatrics, University of California San Diego, La Jolla, California, United States of America; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.
Matthias BlüherUniversity of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, Germany.
Fabrice BonnetUniversity Rennes 1, Rennes, France.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Marcel BruinenbergUniversity of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, Groningen, The Netherlands.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Yii-Der Ida ChenLos Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Simone Claudi-BoehmDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
John ColeVA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Eco J C de GeusDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Lisette C P G M de GrootDepartment of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Maria DimitriouWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Jubao DuanNorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Stefan EnrothScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Elodie EuryCNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Nita G ForouhiMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Nele FriedrichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Pablo V GejmanNorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Bruna GiganteDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nicola GloriosoHypertension and Related Disease Centre, AOU-University of Sassari, Sassari, Italy.
Alan S GoKaiser Permanente, Division of Research, Oakland, California, United States of America.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Jürgen GräßlerDepartment of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yu-Mei GuResearch Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Linda BroerDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Annelies C HamDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, United States of America; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Catharina A HartmanUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Nicholas HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Andrew T HattersleyInstitue of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.
Andrew C HeathWashington University Medical School, St. Louis, Missouri, United States of America.
Anjali K HendersQIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Hans HillegeUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Oddgeir HolmenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Kees G HovinghDepartment Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Jennie HuiPathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; School of Population Health, University of Western Australia, Nedlands, Western Australia, Australia.
Lise L HusemoenResearch Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark.
Nina Hutri-KähönenDepartment of Pediatrics, University of Tampere School of Medicine, Tampere, Finland; Department of Pediatrics,Tampere University Hospital, Tampere, Finland.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany; Institute of Human Genetics, Hannover Medical School, Hanover, Germany.
Philip L De JagerProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts,United States of America.
Shapour JalilzadehWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Torben JørgensenResearch Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, University of Aalborg, Aalborg, Denmark.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
Markus JuonalaDivision of Medicine, Turku University Hospital, Turku, Finland; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Medicine, University of Turku, Turku, Finland.
Stavroula KanoniWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Maria KaraleftheriEchinos Medical Centre, Echinos, Greece.
Kay Tee KhawClinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.
Leena KinnunenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Steven J KittnerVA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America.
Wolfgang KoenigDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Peter KovacsUniversity of Leipzig, IFB Adiposity Diseases, Leipzig, Germany.
Nikolaj T KrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Wolfgang KratzerDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Janine KrügerDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Diana KuhMRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Meena KumariDepartment of Epidemiology and Public Health, UCL, London, United Kingdom.
Theodosios KyriakouWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Epidemiology and Public Health, UCL, London, United Kingdom.
Lars LannfeltDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Chiara LanzaniChair of Nephrology, Università Vita Salute San Raffaele, Segrate (Milan), Italy; Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Segrate (Milan), Italy.
Vaneet LotayDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Karin LeanderDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jaana LindströmDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
Yan-Ping LiuResearch Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Stéphane LobbensCNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Robert LubenStrangeways Research Laboratory Wort's Causeway, Cambridge, United Kingdom.
Valeriya LyssenkoSteno Diabetes Center A/S, Gentofte, Denmark; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden.
Satu MännistöNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Patrik K MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Sigrun MergerDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Lili MilaniEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Grant W MontgomeryQIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Mari NelisEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts, United States of America.
Louis PérusseDepartment of Kinesiology, Laval University, Québec City, Québec, Canada; Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada.
Irene PichlerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Maria G PiliaIstituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.
Anneli PoutaDepartment of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland; Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Myriam RheinbergerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rasmus Ribel-MadsenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marcus RichardsMRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Carlo RivoltaDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Veikko SalomaaNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Alan R SandersNorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Salome ScholtensUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom.
Sylvain SebertInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Sebanti SenguptaCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Bengt SennbladAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Angela SilveiraAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Jan H SmitDepartment of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Thomas H SparsøNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kathleen StirrupsWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Ronald P StolkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Morris A SwertzUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Ann-Christine SyvänenScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Sian-Tsung TanEaling Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Barbara ThorandInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Anke TönjesUniversity of Leipzig, Department of Medicine, Leipzig, Germany.
Angelo TremblayDepartment of Kinesiology, Laval University, Québec City, Québec, Canada.
Emmanouil TsafantakisAnogia Medical Centre, Anogia, Greece.
Peter J van der MostUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada; School of Nutrition, Laval University, Québec City, Québec,Canada.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ryan W WalkerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Roman WennauerDepartment of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany.
Elisabeth WidénInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Gonneke WillemsenDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Tom WilsgaardDepartment of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
M Carola ZillikensNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Suzanne C van DijkDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Natasja M van SchoorEMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; VUMC, Department of Epidemiology and Biostatistics, Amsterdam, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Paul I W de BakkerDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Department of Epidemiology, University Medical Center, Utrecht, The Netherlands.
Jacques S BeckmannSwiss Institute of Bioinformatics, Lausanne, Switzerland.
John BeilbyPathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Sven BergmannSwiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Bernhard O BoehmDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany; Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Singapore, Singapore; Nanyang Technological University, Singapore, Singapore.
Eric BoerwinkleHuman Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Stefan R BornsteinDepartment of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy; University of Sassari, Sassari, Italy.
Daniele CusiDepartment of Health Sciences, University of Milan, Milan, Italy; Institute of Biomedical Technologies, National Institute of Research, Segrate-Milano, Italy.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Jeanette ErdmannDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
Johan G ErikssonNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Denis A EvansRush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom.
Lude FrankeUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden; Department of Public Health & Clinical Medicine, Umeå University Hospital, Umeå, Sweden, Umeå, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Philippe FroguelCNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Ron T GansevoortUniversity of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Ulf GyllenstenScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anders HamstenAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Markku HeliövaaraDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Christian HengstenbergDZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, Germany.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Aroon HingoraniInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Albert HofmanNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Frank HuDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Heikki V HuikuriMedical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
Kristian HveemDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Alan L JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America.
Antti JulaNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
Eero KajantieDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Lambertus A L M KiemeneyRadboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Radboud university medical center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The Netherlands.
Mika KivimakiDepartment of Epidemiology and Public Health, UCL, London, United Kingdom.
Paul B KnektNational Institute for Health and Welfare, Helsinki, Finland.
Heikki A KoistinenNational Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Helsinki University Central Hospital, Department of Medicine and Abdominal Center: Endocrinology, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Jaspal S KoonerEaling Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom.
Seppo KoskinenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Winfried MaerzVth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Nicholas G MartinQIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Guillaume LettreMontreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Douglas F LevinsonStanford University, Stanford, California, United States of America.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Marja-Liisa LokkiTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Pekka MäntyselkäPrimary Health Care Unit, Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland; Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Andres MetspaluEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Braxton D MitchellUniversity of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America.
Frans L MollDepartment of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Markku S NieminenHUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Inger NjølstadDepartment of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Albertine J OldehinkelUniversity of Groningen, University Medical Center, Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen, The Netherlands.
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Lyle J PalmerSchool of Public Health, University of Adelaide, Adelaide, South Australia, Australia; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
Gerard PasterkampExperimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Brenda W PenninxDepartment of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Markus PerolaEstonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Annette PetersDZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ozren PolašekCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany; Department of Neurology, General Central Hospital, Bolzano, Italy.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seatte, Washington, United States of America.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
John D RiouxMontreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Fernando RivadeneiraNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Jerome I RotterLos Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Hester M den RuijterExperimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Juha SaltevoDepartment of Medicine, Central Finland Central Hospital, Jyväskylä, Finland.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Heribert SchunkertDZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, Germany.
Peter E H SchwarzDepartment of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Alan R ShuldinerProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, United States of America.
Juha SinisaloHUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Jan A StaessenResearch Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D VitaK Group, Maastricht University, Maastricht, The Netherlands.
Bandinelli StefaniaGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Unnur ThorsteinsdottirdeCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Michael StumvollUniversity of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, Germany.
Jean-Claude TardifMontreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Jaakko TuomilehtoDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria; Instituto de Investigacion Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
André G UitterlindenNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland.
André L M VerbeekRadboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.
Sita H VermeulenRadboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Jorma S ViikariDepartment of Medicine, University of Turku, Turku, Finland.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland.
Gérard WaeberDepartment of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland.
Mark WalkerProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.
Henri WallaschofskiInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Eleftheria ZegginiWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
CHARGE Consortium
DIAGRAM Consortium
GLGC Consortium
Global-BPGen Consortium
ICBP Consortium
MAGIC Consortium
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Deborah J CleggDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
L Adrienne CupplesNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Cashell E JaquishNational Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, United States of America.
D C RaoDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Goncalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Inês BarrosoWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United Kingdom; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United Kingdom.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Panos DeloukasWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Caroline S FoxNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
Leif C GroopLund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland.
David J HunterBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Erik IngelssonScience for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Robert C KaplanDepartment of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Jeffrey R O'ConnellProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
David SchlessingerNational Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, United Kingdom.
Kari StefanssondeCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
Joel N HirschhornBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Cecilia M LindgrenBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Kari E NorthCarolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Zoltán KutalikSwiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Ruth J F LoosMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2003 to 2026
$40.4MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MStable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shuibing Chen · 2015 to 2026
$27.7MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0MBritish Heart Foundation RG/10/12/28456British Heart Foundation RG/13/2/30098Cancer Research UK 14136Intramural NIH HHS Z01 HG000024Medical Research Council G0000934Medical Research Council G0401527Medical Research Council G0600705Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G1000143Medical Research Council G1001799Medical Research Council G1002319Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12019/1Medical Research Council MR/K002414/1Medical Research Council MR/K013351/1Medical Research Council MR/N01104X/1NCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA047988NCI NIH HHS U01 CA098233NCI NIH HHS UM1 CA182913NCRR NIH HHS M01 RR016500NCRR NIH HHS U54 RR020278NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG002651NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01 HG004436NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087647NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087676NHLBI NIH HHS R01 HL087679NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL091823NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084729NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U01 HL105198NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIAMS NIH HHS F32 AR059469NIAMS NIH HHS P60 AR030701NIAMS NIH HHS P60 AR049465NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG012109NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028555NIA NIH HHS R01 AG030146NIA NIH HHS R37 AG013196NIA NIH HHS R56 AG023629NIA NIH HHS RF1 AG015819NIA NIH HHS T32 AG000219NICHD NIH HHS P2C HD050924NIDA NIH HHS R01 DA012854NIDA NIH HHS R56 DA012854NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK062418NIGMS NIH HHS U01 GM074518NIMHD NIH HHS R01 MD009164NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH063706NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS RL1 MH083268NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470NIMH NIH HHS U24 MH068457NINDS NIH HHS R01 NS045012NINDS NIH HHS U01 NS069208Versus Arthritis 20109Versus Arthritis 20308Wellcome Trust 098017Wellcome Trust 098381Wellcome Trust 098395
Abstract
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Indexed as
Body Mass IndexGenetic Predisposition to DiseaseGenome-Wide Association StudyAdultAgedAge FactorsBody SizeChromosome MappingFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideSex CharacteristicsWaist-Hip RatioWhite People
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