Evidence map›Paper›PMID 26426945›Full record

ArticleEpidemiology (Cambridge, Mass.)2016

Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA.

Joan A Casey, David A Savitz, Sara G Rasmussen, Elizabeth L Ogburn, Jonathan Pollak, Dione G Mercer, Brian S Schwartz

Abstract readVideo-Audio Media
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. The public health impacts of mining in Australia.The Medical journal of Australia · 2025
    Pooled it
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  11. Impact of oil and gas boom and busts on working-age mortality in the U.S.Environmental epidemiology (Philadelphia, Pa.) · 2025
    Article
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Joan A CaseyFrom the aDepartment of Environmental Health Sciences, bDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; cDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD; dDepartment of Epidemiology, Brown University School of Public Health, Providence, RI; eDepartment of Obstetrics and Gynecology, Alpert School of Medicine, Brown University, Providence, RI; fRobert Wood Johnson Foundation Health and Society Scholars Program, UC San Francisco and UC Berkeley, San Franciso, CA; and gCenter for Health Research, Geisinger Health System, Danville, PA.
David A Savitz
Sara G Rasmussen
Elizabeth L Ogburn
Jonathan Pollak
Dione G Mercer
Brian S Schwartz

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
Marcellus shale development, respiratory & reproductive outcomes in PennsylvaniaR21ES023675 · NIEHS · GEISINGER CLINIC · PI SCHWARTZ, BRIAN SETH · 2014 to 2015
$480k
NIEHS NIH HHS ES023675-01NIEHS NIH HHS ES07141NIEHS NIH HHS R21 ES023675NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

backgroundUnconventional natural gas development has expanded rapidly. In Pennsylvania, the number of producing wells increased from 0 in 2005 to 3,689 in 2013. Few publications have focused on unconventional natural gas development and birth outcomes.

methodsWe performed a retrospective cohort study using electronic health record data on 9,384 mothers linked to 10,946 neonates in the Geisinger Health System from January 2009 to January 2013. We estimated cumulative exposure to unconventional natural gas development activity with an inverse-distance squared model that incorporated distance to the mother's home; dates and durations of well pad development, drilling, and hydraulic fracturing; and production volume during the pregnancy. We used multilevel linear and logistic regression models to examine associations between activity index quartile and term birth weight, preterm birth, low 5-minute Apgar score and small size for gestational age birth, while controlling for potential confounding variables.

resultsIn adjusted models, there was an association between unconventional natural gas development activity and preterm birth that increased across quartiles, with a fourth quartile odds ratio of 1.4 (95% confidence interval = 1.0, 1.9). There were no associations of activity with Apgar score, small for gestational age birth, or term birth weight (after adjustment for year). In a posthoc analysis, there was an association with physician-recorded high-risk pregnancy identified from the problem list (fourth vs. first quartile, 1.3 [95% confidence interval = 1.1, 1.7]).

conclusionPrenatal residential exposure to unconventional natural gas development activity was associated with two pregnancy outcomes, adding to evidence that unconventional natural gas development may impact health.See Video Abstract at http://links.lww.com/EDE/B14.

Indexed as

Apgar ScoreBirth WeightPregnancy, High-RiskCohort StudiesElectronic Health RecordsFemaleHumansHydraulic FrackingInfant, NewbornInfant, Small for Gestational AgeLinear ModelsLogistic ModelsMaleMaternal ExposureMultilevel AnalysisNatural GasNatural Gas

Identifiers

PMID26426945
PMCPMC4738074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.