Evidence map›Paper›PMID 26426884›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2016

Cesarean delivery is not associated with decreased at-birth fracture rates in osteogenesis imperfecta.

S Bellur, M Jain, D Cuthbertson, D Krakow, J R Shapiro, R D Steiner, P A Smith, M B Bober, T Hart, J Krischer and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. A Sporadic Case ofGenes · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Current Overview of Osteogenesis Imperfecta.Medicina (Kaunas, Lithuania) · 2021
    Review
  15. Article
  16. Article
  17. Pamidronate Administration During Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  18. Mobility in osteogenesis imperfecta: a multicenter North American study.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 2 countries.

S BellurDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
M JainDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
D CuthbertsonCollege of Medicine, University of South Florida, Tampa, Florida, USA.
D KrakowDepartment of Orthopedic Surgery, University of California, Los Angeles, California, USA.
J R ShapiroDepartment of Bone and Osteogenesis Imperfecta, Kennedy Krieger Institute, Baltimore, Maryland, USA.
R D SteinerDepartment of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-4177-4590
P A SmithShriners Hospitals for Children, Chicago, Illinois, USA.
M B BoberDivision of Medical Genetics, Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.ORCID 0000-0002-6178-1264
T HartOsteogenesis Imperfecta Foundation, Gaithersburg, Maryland, USA.
J KrischerCollege of Medicine, University of South Florida, Tampa, Florida, USA.
M MullinsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
P H ByersDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-7786-7030
M PepinDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-6299-2971
M DurigovaDepartment of Orthopedic Surgery, Shriners Hospital for Children and McGill University, Montreal, Québec, Canada.
F H GlorieuxDepartment of Orthopedic Surgery, Shriners Hospital for Children and McGill University, Montreal, Québec, Canada.
F RauchDepartment of Orthopedic Surgery, Shriners Hospital for Children and McGill University, Montreal, Québec, Canada.
V R SuttonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
B LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Members of the BBD Consortium
S C NagamaniDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Baylor College of Medicine · USMontreal Children's Hospital · CAUniversity of South Florida · USUniversity of Washington Medical Center · USDuPont (United States) · USKennedy Krieger Institute · USMarshfield Clinic · USOsteogenesis Imperfecta Foundation · USShriners Hospitals for Children - Chicago · USUniversity of California, Los Angeles · US

Funding

Project 3: 3D ImagingU54AR068069 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee · 2014 to 2026
$19.3M
MEDICAL GENETICS RESEARCH FELLOWSHIP PROGRAMT32GM007526 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee · 1985 to 2026
$11.4M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, SAMACO, RODNEY C · 2014 to 2019
$7.8M
Doris Duke Charitable Foundation 2013095NIAMS NIH HHS U54 AR068069NICHD NIH HHS U54 HD083092NIGMS NIH HHS T32 GM007526
6 · The paper itself

Abstract

purposeOsteogenesis imperfecta (OI) predisposes to recurrent fractures. Patients with the moderate to severe forms of OI present with antenatal fractures, and the mode of delivery that would be safest for the fetus is not known.

methodsWe conducted systematic analyses of the largest cohort of individuals with OI (n = 540) enrolled to date in the OI Linked Clinical Research Centers. Self-reported at-birth fracture rates were compared among individuals with OI types I, III, and IV. Multivariate analyses utilizing backward-elimination logistic regression model building were performed to assess the effect of multiple covariates, including method of delivery, on fracture-related outcomes.

resultsWhen accounting for other covariates, at-birth fracture rates did not differ based on whether delivery was by vaginal route or by cesarean delivery (CD). Increased birth weight conferred higher risk for fractures irrespective of the delivery method. In utero fracture, maternal history of OI, and breech presentation were strong predictors for choosing CD.

conclusionOur study, the largest to analyze the effect of various factors on at-birth fracture rates in OI, shows that CD is not associated with decreased fracture rate. With the limitation that the fracture data were self-reported in this cohort, these results suggest that CD should be performed only for other maternal or fetal indications, not for the sole purpose of fracture prevention in OI.Genet Med 18 6, 570-576.

Indexed as

Prenatal DiagnosisBirth WeightCesarean SectionFemaleFractures, BoneHumansInfant, NewbornLogistic ModelsMaleOsteogenesis ImperfectaPregnancy

Identifiers

PMID26426884
PMCPMC4818203
OpenAlexW2150740651

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.