ArticleJournal of anatomy2016
Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.
Article in Journal of anatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Demystifying machine learning approaches in digital bone imaging using microCT and HRpQCT.Bone reports · 2026Review
- Palatal segment contributions to midfacial anterior-posterior growth.Journal of anatomy · 2025Article
- Dentition of the Mugharet El'Aliya Fossil Human Maxilla, Morocco.American journal of biological anthropology · 2025Article
- Palatal segment contributions to midfacial anterior-posterior growth.bioRxiv : the preprint server for biology · 2024Article
- Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.BMC genomics · 2023Article
- Merging morphological and genetic evidence to assess hybridization in Western Eurasian late Pleistocene hominins.Nature ecology & evolution · 2022Article
- The genetic basis of neurocranial size and shape across varied lab mouse populations.Journal of anatomy · 2022Article
- Modelling the shape of the pig scapula.Genetics, selection, evolution : GSE · 2020Article
- A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Integration and the Developmental Genetics of Allometry.Integrative and comparative biology · 2019Review
- Hybridization in human evolution: Insights from other organisms.Evolutionary anthropology · 2019Review
- The effect of automated landmark identification on morphometric analyses.Journal of anatomy · 2019Article
- A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size.G3 (Bethesda, Md.) · 2019Article
- Craniomandibular form and body size variation of first generation mouse hybrids: A model for hominin hybridization.Journal of human evolution · 2018Article
- Creating diversity in mammalian facial morphology: a review of potential developmental mechanisms.EvoDevo · 2018Review
- Article
- A population level atlas of Mus musculus craniofacial skeleton and automated image-based shape analysis.Journal of anatomy · 2017Article
- The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.G3 (Bethesda, Md.) · 2017Article
- Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology.Journal of inherited metabolic disease · 2017Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
Using eight inbred founder strains of the mouse Collaborative Cross (CC) project and their reciprocal F1 hybrids, we quantified variation in craniofacial morphology across mouse strains, explored genetic contributions to craniofacial variation that distinguish the founder strains, and tested whether specific or summary measures of craniofacial shape display stronger additive genetic contributions. This study thus provides critical information about phenotypic diversity among CC founder strains and about the genetic contributions to this phenotypic diversity, which is relevant to understanding the basis of variation in standard laboratory strains and natural populations. Craniofacial shape was quantified as a series of size-adjusted linear dimensions (RDs) and by principal components (PC) analysis of morphological landmarks captured from computed tomography images from 62 of the 64 reciprocal crosses of the CC founder strains. We first identified aspects of skull morphology that vary between these phenotypically 'normal' founder strains and that are defining characteristics of these strains. We estimated the contributions of additive and various non-additive genetic factors to phenotypic variation using diallel analyses of a subset of these strongly differing RDs and the first eight PCs of skull shape variation. We find little difference in the genetic contributions to RD measures and PC scores, suggesting fundamental similarities in the magnitude of genetic contributions to both specific and summary measures of craniofacial phenotypes. Our results indicate that there are stronger additive genetic effects associated with defining phenotypic characteristics of specific founder strains, suggesting these distinguishing measures are good candidates for use in genotype-phenotype association studies of CC mice. Our results add significantly to understanding of genotype-phenotype associations in the skull, which serve as a foundation for modeling the origins of medically and evolutionarily relevant variation.
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