Trial reportPloS one2015
Efficacy of a Community-Based Physical Activity Program KM2H2 for Stroke and Heart Attack Prevention among Senior Hypertensive Patients: A Cluster Randomized Controlled Phase-II Trial.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Effectiveness of booster strategies to promote physical activity maintenance: a systematic review and meta-analysis.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Group-delivered interventions for lowering blood pressure in hypertension: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Pooled it
- Role of Health Care Professionals in the Success of Blood Pressure Control Interventions in Patients With Hypertension: A Meta-Analysis.Circulation. Cardiovascular quality and outcomes · 2024Pooled it
- The effects of co-designed physical activity interventions in older adults: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Exercise-based cardiac rehabilitation for coronary heart disease.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- Self-Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association.Journal of the American Heart Association · 2017Guideline
- Trial
- The Effects of a Theory-Based Patient Portal e-Learning Program for Older Adults with Chronic Illnesses.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2019Trial
- Effect of pedometer-based walking interventions on long-term health outcomes: Prospective 4-year follow-up of two randomised controlled trials using routine primary care data.PLoS medicine · 2019Trial
- Persistent effect at 30-month post intervention of a community-based randomized trial of KM2HThe international journal of behavioral nutrition and physical activity · 2018Trial
- Lifestyle interventions for cardiometabolic health.Nature medicine · 2024Review
- Exploring the Priorities of Older Adults in Managing Urinary Incontinence: a Patient-Oriented Research Approach.Canadian geriatrics journal : CGJ · 2024Article
- Effectiveness of Community-Based Rehabilitation (CBR) Centers for Improving Physical Fitness for Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Annals of rehabilitation medicine · 2024Article
- Article
- Effects of Auricular Point Acupressure with Lifestyle Interventions on Cerebrovascular Function among Adults with High Stroke Risk: A Randomized Controlled Study.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- The Effectiveness of Tailored Interactive Multimedia Software based on the Trans-Theoretical Model for the Promotion of Physical Activity Behaviours.The Malaysian journal of medical sciences : MJMS · 2022Article
- MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats.Journal of physiology and biochemistry · 2022Article
- Focus on blood pressure levels and variability in the early phase of acute ischemic stroke with hypertension and carotid stenosis.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Tree-Based Machine Learning to Identify and Understand Major Determinants for Stroke at the Neighborhood Level.Journal of the American Heart Association · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy of the program Keep Moving toward Healthy Heart and Healthy Brain (KM2H2) in encouraging physical activities for the prevention of heart attack and stroke among hypertensive patients enrolled in the Community-Based Hypertension Control Program (CBHCP).
designCluster randomized controlled trial with three waves of longitudinal assessments at baseline, 3 and 6 months post intervention.
settingCommunity-based and patient-centered self-care for behavioral intervention in urban settings of China.
participantsA total of 450 participants diagnosed with hypertension from 12 community health centers in Wuhan, China were recruited, and were randomly assigned by center to receive either KM2H2 plus standard CBHCP care (6 centers and 232 patients) or the standard care only (6 centers and 218 patients).
interventionKM2H2 is a behavioral intervention guided by the Transtheoretical Model, the Model of Personalized Medicine and Social Capital Theory. It consists of six intervention sessions and two booster sessions engineered in a progressive manner. The purpose is to motivate and maintain physical activities for the prevention of heart attack and stroke. OUTCOME MEASURES: Heart attack and stroke (clinically diagnosed, primary outcome), blood pressure (measured, secondary outcome), and physical activity (self-report, tertiary outcome) were assessed at the individual level during the baseline, 3- and 6-month post-intervention.
resultsRelative to the standard care, receiving KM2H2 was associated with significant reductions in the incidence of heart attack (3.60% vs. 7.03%, p < .05) and stroke (5.11% vs. 9.90%, p<0.05), and moderate reduction in blood pressure (-3.72 mmHg in DBP and -2.92 mmHg in DBP) at 6-month post-intervention; and significant increases in physical activity at 3- (d = 0.53, 95% CI: 0.21, 0.85) and 6-month (d = 0.45, 95% CI: 0.04, 0.85) post-intervention, respectively.
conclusionThe program KM2H2 is efficacious to reduce the risk of heart attack and stroke among senior patients who are on anti-hypertensive medication. Findings of this study provide solid data supporting a formal phase-III trial to establish the effectiveness of KM2H2 for use in community settings for prevention.
trial registrationISRCTN Register ISRCTN12608966.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.