Evidence map›Paper›PMID 26426341›Full record

ArticlePloS one2015

External Validation of Models for Prediction of Lymph Node Metastasis in Urothelial Carcinoma of the Bladder.

Ja Hyeon Ku, Myong Kim, Seok-Soo Byun, Hyeon Jeong, Cheol Kwak, Hyeon Hoe Kim, Sang Eun Lee

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ja Hyeon KuDepartment of Urology, Seoul National University Hospital, Seoul, Korea.
Myong KimDepartment of Urology, Seoul National University Hospital, Seoul, Korea.
Seok-Soo ByunDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Hyeon JeongDepartment of Urology, SMG-SNU Boramae Medical Center, Seoul, Korea.
Cheol KwakDepartment of Urology, Seoul National University Hospital, Seoul, Korea.
Hyeon Hoe KimDepartment of Urology, Seoul National University Hospital, Seoul, Korea.
Sang Eun LeeDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Seoul National University Hospital · KRSeoul National University Bundang Hospital · KRSNUH SMG-SNU Boramae Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo externally validate models to predict LN metastsis; Karakiewicz nomogram, clinical nodal staging score (cNSS), and pathologic nodal staging score (pNSS) using a different cohort. MATERIALS AND

methodsClinicopathologic data from 500 patients who underwent radical cystectomy and pelvic lymphadenectomy were analyzed. The overall predictive values of models were compared with the criteria of overall performance, discrimination, calibration, and clinical usefulness.

resultsPresence of pN+ stages was recorded in 117 patients (23.4%). Agreement between clinical and pathologic stage was noted in 174 (34.8%). Based on Nagelkerke's peudo-R2 and brier score, pNSS demonstrated best overall performance. Area under the receiver operating characteristics curve, showed that pNSS had the best discriminatory ability. In all models, calibration was on average correct (calibration-in-the-large coefficient = zero). On decision curve analysis, pNSS performed better than other models across a wide range of threshold probabilities.

conclusionsWhen compared to pNSS, current precystectomy models such as the Karakiewicz nomogram and cNSS cannot predict the probability of LN metastases accurately. The findings suggest that the application of pNSS to Asian patients is feasible.

Indexed as

Models, StatisticalAdultAgedAged, 80 and overCarcinoma, Transitional CellCohort StudiesFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingROC CurveUrinary Bladder NeoplasmsYoung Adult

Identifiers

PMID26426341
PMCPMC4591286
OpenAlexW1846824758

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.