Evidence map›Paper›PMID 26426314›Full record

SynthesisChest2016

Treatment of Unexplained Chronic Cough: CHEST Guideline and Expert Panel Report.

Peter Gibson, Gang Wang, Lorcan McGarvey, Anne E Vertigan, Kenneth W Altman, Surinder S Birring, CHEST Expert Cough Panel

3 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Chest, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 165 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 14 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03457610 nacompletednot on this map

Speech Therapy in the Management of Difficult-to-treat Chronic Cough

TypeinterventionalSponsorMedical University of WarsawRan2016 to 2020Enrolled30ConditionsCough, Speech TherapyArmsSpeech and language intervention
NCT05665244 recruitingnot on this mapstarted 2022, after this paper: background citation

To Determine the Efficacy of Topical Cryotherapy on Supraglottic Laryngeal Mucosa in the Treatment of Chronic Neurogenic Cough in Adult Patients

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2022 to 2027Enrolled28ConditionsUpper-Airway Cough SyndromeArmsLaryngeal cryotherapy, Cryoprobe
NCT07659860 recruitingnot on this mapstarted 2022, after this paper: background citation

Does Chronic Cough Lead to Injury and Remodelling of the Lower Airways?

TypeobservationalSponsorMedical University of WarsawRan2022 to 2026Enrolled40ConditionsChronic CoughArmschest computed tomography and bronchoscopy
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 14 syntheses or guidelines pooled it, 346 citations in OpenAlex.

  1. Effect of Superior Laryngeal Nerve Block for Neurogenic Cough: A Single-Arm Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Guideline
  10. Swiss Recommendations for the Follow-Up and Treatment of Pulmonary Long COVID.Respiration; international review of thoracic diseases · 2021
    Guideline
  11. Speech and language therapy for management of chronic cough.The Cochrane database of systematic reviews · 2019
    Pooled it
  12. Pooled it
  13. Codeine versus placebo for chronic cough in children.The Cochrane database of systematic reviews · 2016
    Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE).American journal of respiratory and critical care medicine · 2025
    Trial
  19. Trial
  20. Trial

105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Peter GibsonHunter Medical Research Institute, New South Wales, Australia. Electronic address: peter.gibson@hnehealth.nsw.gov.au.
Gang WangSichuan University, West China Hospital, Chengdu, China.
Lorcan McGarveyThe Queen's University Belfast, Belfast, England.
Anne E VertiganJohn Hunter Hospital, New South Wales, Australia.
Kenneth W AltmanBaylor College of Medicine, Houston, TX.
Surinder S BirringDivision of Asthma, Allergy and Lung Biology, King's College London, London, England.
CHEST Expert Cough Panel
Hunter Medical Research Institute · AUBaylor College of Medicine · USJohn Hunter Hospital · AUKing's College London · GBQueen's University Belfast · GBSichuan University · CNWest China Hospital of Sichuan University · CN

Funding

Central Mechanisms of Airway ProtectionR01HL103415 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, DAVENPORT, PAUL W · 2010 to 2013
$2.2M
Medical Research Council MR/K015141/1
6 · The paper itself

Abstract

backgroundUnexplained chronic cough (UCC) causes significant impairments in quality of life. Effective assessment and treatment approaches are needed for UCC.

methodsThis systematic review of randomized controlled trials (RCTs) asked: What is the efficacy of treatment compared with usual care for cough severity, cough frequency, and cough-related quality of life in patients with UCC? Studies of adults and adolescents aged > 12 years with a chronic cough of > 8 weeks' duration that was unexplained after systematic investigation and treatment were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the American College of Chest Physicians organization methodology.

resultsEleven RCTs and five systematic reviews were included. The 11 RCTs reported data on 570 participants with chronic cough who received a variety of interventions. Study quality was high in 10 RCTs. The studies used an assortment of descriptors and assessments to identify UCC. Although gabapentin and morphine exhibited positive effects on cough-related quality of life, only gabapentin was supported as a treatment recommendation. Studies of inhaled corticosteroids (ICS) were affected by intervention fidelity bias; when this factor was addressed, ICS were found to be ineffective for UCC. Esomeprazole was ineffective for UCC without features of gastroesophageal acid reflux. Studies addressing nonacid gastroesophageal reflux disease were not identified. A multimodality speech pathology intervention improved cough severity.

conclusionsThe evidence supporting the diagnosis and management of UCC is limited. UCC requires further study to establish agreed terminology and the optimal methods of investigation using established criteria for intervention fidelity. Speech pathology-based cough suppression is suggested as a treatment option for UCC. This guideline presents suggestions for diagnosis and treatment based on the best available evidence and identifies gaps in our knowledge as well as areas for future research.

Indexed as

AdolescentAdultAlgorithmsChildChronic DiseaseCoughDecision TreesHumansPractice Guidelines as Topicchronic coughcough frequency and severitycough-related quality of lifetreatmentunexplained cough

Identifiers

PMID26426314
PMCPMC5831652
OpenAlexW2222678573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.