Evidence map›Paper›PMID 26426270›Full record

Trial reportPLoS neglected tropical diseases2015

The Effect of Deworming on Growth in One-Year-Old Children Living in a Soil-Transmitted Helminth-Endemic Area of Peru: A Randomized Controlled Trial.

Serene A Joseph, Martín Casapía, Antonio Montresor, Elham Rahme, Brian J Ward, Grace S Marquis, Lidsky Pezo, Brittany Blouin, Mathieu Maheu-Giroux, Theresa W Gyorkos

Erratum issued Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01314937 (Improving Early Childhood Growth and Development in Resource-poor LMICs by Incorporating Deworming in Integrated Child Health Care), which is not on this map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01314937 phase4completednot on this map

Improving Early Childhood Growth and Development in Resource-poor LMICs by Incorporating Deworming in Integrated Child Health Care

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2011 to 2013Enrolled1,760ConditionsMalnutrition, Intestinal Diseases, ParasiticArmsMebendazole, Usual care
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Drivers of stunting reduction in Peru: a country case study.The American journal of clinical nutrition · 2020
    Pooled it
  3. Anthelmintic drugs for treating ascariasis.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Serene A JosephMcGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, Canada; Research Institute of the McGill University Health Centre, Division of Clinical Epidemiology, Montréal, Québec, Canada.
Martín CasapíaAsociación Civil Selva Amazónica, Iquitos, Peru.
Antonio MontresorDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Elham RahmeResearch Institute of the McGill University Health Centre, Division of Clinical Epidemiology, Montréal, Québec, Canada; McGill University, Department of Medicine, Montréal, Québec, Canada.
Brian J WardJD MacLean Centre for Tropical Diseases, McGill University, Department of Medicine, Montréal, Québec, Canada; National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Grace S MarquisMcGill University, School of Dietetics and Human Nutrition, Sainte Anne-de-Bellevue, Québec, Canada.
Lidsky PezoAsociación Civil Selva Amazónica, Iquitos, Peru.
Brittany BlouinMcGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, Canada; Research Institute of the McGill University Health Centre, Division of Clinical Epidemiology, Montréal, Québec, Canada.
Mathieu Maheu-GirouxDepartment of Infectious Disease Epidemiology, Imperial College London, St. Mary's Hospital, London, United Kingdom.
Theresa W GyorkosMcGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, Canada; Research Institute of the McGill University Health Centre, Division of Clinical Epidemiology, Montréal, Québec, Canada; McGill University, Department of Medicine, Montréal, Québec, Canada; JD MacLean Centre for Tropical Diseases, McGill University, Department of Medicine, Montréal, Québec, Canada.
McGill University · CAAsociación para la Conservación de la Cuenca Amazónica · PEMcGill University Health Centre · CAImperial College London · GBWorld Health Organization · CH

Funding

Soil-Transmitted Helminthiases (STH) and DewormingP50AI098574 · NIAID · CIVIL ASSOCIATION OF THE AMAZON JUNGLE · PI CASTILLO, JUAN M · 2012 to 2016
$1.5M
CIHR MOP-110969NIAID NIH HHS P50 AI098574World Health Organization 001
6 · The paper itself

Abstract

backgroundAppropriate health and nutrition interventions to prevent long-term adverse effects in children are necessary before two years of age. One such intervention may include population-based deworming, recommended as of 12 months of age by the World Health Organization in soil-transmitted helminth (STH)-endemic areas; however, the benefit of deworming has been understudied in early preschool-age children. METHODOLOGY/PRINCIPAL

findingsA randomized, double-blind, placebo-controlled trial was conducted to determine the effect of deworming (500 mg single-dose crushed mebendazole tablet) on growth in one-year-old children in Iquitos, Peru. Children were enrolled during their routine 12-month growth and development clinic visit and followed up at their 18 and 24-month visits. Children were randomly allocated to: Group 1: deworming at 12 months and placebo at 18 months; Group 2: placebo at 12 months and deworming at 18 months; Group 3: deworming at both 12 and 18 months; or Group 4: placebo at both 12 and 18 months (i.e. control group). The primary outcome was weight gain at the 24-month visit. An intention-to-treat approach was used. A total of 1760 children were enrolled between September 2011 and June 2012. Follow-up of 1563 children (88.8%) was completed by July 2013. STH infection was of low prevalence and predominantly light intensity in the study population. All groups gained between 1.93 and 2.05 kg on average over 12 months; the average difference in weight gain (kg) compared to placebo was: 0.05 (95% CI: -0.05, 0.17) in Group 1; -0.07 (95%CI: -0.17, 0.04) in Group 2; and 0.04 (95%CI: -0.06, 0.14) in Group 3. There was no statistically significant difference in weight gain in any of the deworming intervention groups compared to the control group.

conclusionsOverall, with one year of follow-up, no effect of deworming on growth could be detected in this population of preschool-age children. Low baseline STH prevalence and intensity and/or access to deworming drugs outside of the trial may have diluted the potential effect of the intervention. Additional research is required to overcome these challenges and to contribute to strengthening the evidence base on deworming.

trial registrationClinicalTrials.gov (NCT01314937).

Indexed as

Endemic DiseasesBody HeightBody WeightDouble-Blind MethodFecesFemaleHelminthiasisHumansInfantMalePatient ComplianceSoilTime FactorsSoil

Identifiers

PMID26426270
PMCPMC4591279
OpenAlexW1801280500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.