ArticlePloS one2015
Transcriptomic Analysis of Ovaries from Pigs with High And Low Litter Size.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Whole-genome sequencing identified candidate genes associated with high and low litter size in Chuanzhong black goats.Frontiers in veterinary science · 2024Article
- 2,5-Hexanedione Affects Ovarian Granulosa Cells in Swine by Regulating theVeterinary sciences · 2023Article
- Article
- Differential MicroRNA Expression in Porcine Endometrium Related to Spontaneous Embryo Loss during Early Pregnancy.International journal of molecular sciences · 2022Article
- Ovarian Transcriptomic Analysis of Ninghai Indigenous Chickens at Different Egg-Laying Periods.Genes · 2022Article
- Time Series Ovarian Transcriptome Analyses of the Porcine Estrous Cycle Reveals Gene Expression Changes during Steroid Metabolism and Corpus Luteum Development.Animals : an open access journal from MDPI · 2022Article
- TIMP1 may affect goat prolificacy by regulating biological function of granulosa cells.Archives animal breeding · 2022Article
- Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats.Journal of Zhejiang University. Science. B · 2021Article
- Comparative transcriptomic analysis of ovaries from high and low egg-laying Lingyun black-bone chickens.Veterinary medicine and science · 2021Article
- Differences in gene expression and variable splicing events of ovaries between large and small litter size in Chinese Xiang pigs.Porcine health management · 2021Article
- Article
- Integrated analysis of lncRNA, miRNA and mRNA reveals novel insights into the fertility regulation of large white sows.BMC genomics · 2020Article
- Comparative analysis of the ovarian transcriptome reveals novel insights into fertility differences in Large White sows.Genes & genomics · 2020Article
- Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs.Animals : an open access journal from MDPI · 2020Article
- Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase.BMC genomics · 2020Article
- Serial gene co-expression network approach to mine biological meanings from integrated transcriptomes of the porcine endometrium during estrous cycle.Functional & integrative genomics · 2020Article
- Genome-Wide Differential Expression Profiling of Ovarian circRNAs Associated With Litter Size in Pigs.Frontiers in genetics · 2019Article
- Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods.BMC genomics · 2018Article
- Transcriptome analysis reveals candidate genes involved in splay leg syndrome in piglets.Journal of applied genetics · 2018Article
- Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome.RSC advances · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Litter size is one of the most important economic traits for pig production as it is directly related to the production efficiency. Litter size is affected by interactions between multiple genes and the environment. While recent studies have identified some genes associated with prolificacy in pigs, transcriptomic studies of specific genes affecting litter size in porcine ovaries are rare. In order to identify candidate genes associated with litter size in swine, we assessed gene expression differences between the ovaries of Yorkshire pigs with extremely high and low litter sizes using the RNA-Seq method. A total of 1 243 differentially expressed genes were identified: 897 genes were upregulated and 346 genes were downregulated in high litter size ovary samples compared with low litter size ovary samples. A large number of these genes related to steroid hormone regulation in animal ovaries, including 59 Gene Ontology terms and 27 Kyoto Encyclopedia of Genes and Genomes pathways involved in steroid biosynthesis and ovarian steroidogenesis. From these differentially expressed genes, we identified a total of 11 genes using a bioinformatics screen that may be associated with high litter size in Yorkshire pigs. These results provide a list of new candidate genes for porcine litter size and prolificacy to be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.