Evidence map›Paper›PMID 26426068›Full record

ReviewBiomolecules2015

Impact of Alcohol on Glycemic Control and Insulin Action.

Jennifer L Steiner, Kristen T Crowell, Charles H Lang

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Trial
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  5. Trial
  6. Article
  7. Review
  8. Review
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  13. Observational
  14. Article
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  17. Antidiabetic Effects and Mechanisms of Action of Uncaria gambir Roxb. in Diabetic Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jennifer L SteinerDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA. jls1075@psu.edu.
Kristen T CrowellDepartment of Surgery, Penn State College of Medicine, Hershey, PA 17033, USA. kcrowell1@hmc.psu.edu.
Charles H LangDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA. clang@psu.edu.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Regulation of Nutrient Sensing and Muscle Wasting by AlcoholR37AA011290 · NIAAA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LANG, CHARLES H. · 2012 to 2021
$3.4M
Modulation of Contraction-Induced Changes in Muscle mTOR Signaling by AlcoholF32AA023422 · NIAAA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI STEINER, JENNIFER LYNN · 2014 to 2016
$158k
Zinc Homeostasis and Muscle Catabolism During Sepsis and RecoveryF32GM112401 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CROWELL, KRISTEN T · 2014 to 2015
$109k
NIAAA NIH HHS F32 AA023422NIAAA NIH HHS F32 AA23422NIAAA NIH HHS R37 AA011290NIGMS NIH HHS F32 GM112401
6 · The paper itself

Abstract

Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to the increased morbidity and mortality in individuals with alcohol use disorder. This review focuses on the glucose metabolic effects of alcohol, primarily in the muscle, liver and adipose tissue, under basal postabsorptive conditions and in response to insulin stimulation. While there is a relatively extensive literature in this area, results are often discordant and extrapolating between models and tissues is fraught with uncertainty. Comparisons between data generated in experimental cell and animals systems will be contrasted with that obtained from human subjects as often times results differ. Further, the nutritional status is also an important component of the sometimes divergent findings pertaining to the effects of alcohol on the regulation of insulin and glucose metabolism. This work is relevant as the contribution of alcohol intake to the development or exacerbation of type 2 diabetes remains ill-defined and a multi-systems approach is likely needed as both alcohol and diabetes affect multiple targets within the body.

Indexed as

Alcohol-Related DisordersAnimalsBlood GlucoseEthanolHumansInsulinLiverMuscle, SkeletalBlood GlucoseEthanolInsulinalcohol use disorderethanolinsulin actionliverskeletal muscle

Identifiers

PMID26426068
PMCPMC4693236
OpenAlexW2104643926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.