ArticleMembranes2015
The Effect of the Nonlinearity of the Response of Lipid Membranes to Voltage Perturbations on the Interpretation of Their Electrical Properties. A New Theoretical Description.
Article in Membranes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A charge conservative finite volume discretization of the Hodgkin-Huxley model.Journal of computational neuroscience · 2026Article
- Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability.Membranes · 2026Article
- AI-Resolved Protein Energy Landscapes, Electrodynamics, and Fluidic Microcircuits as a Unified Framework for Predicting Neurodegeneration.International journal of molecular sciences · 2026Review
- High-frequency signals: a comparison between the cable equation and telegrapher's equations in nerves.BMC biomedical engineering · 2025Article
- Bilayer Lipid Membrane as Memcapacitance: Capacitance-Voltage Pinched Hysteresis and Negative Insertion Conductance.Membranes · 2023Article
- The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability.Frontiers in neuroscience · 2023Article
- Importance of Hydroxide Ion Conductivity Measurement for Alkaline Water Electrolysis Membranes.Membranes · 2022Article
- Fabrication and electromechanical characterization of freestanding asymmetric membranes.Biophysical journal · 2021Article
- Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage.Membranes · 2021Article
- Real-Time Impedance Detection of Intra-Articular Space in a Porcine Model Using a Monopolar Injection Needle.Sensors (Basel, Switzerland) · 2020Article
- Non-linear Conductance, Rectification, and Mechanosensitive Channel Formation of Lipid Membranes.Frontiers in cell and developmental biology · 2020Article
- A Physical Perspective to the Inductive Function of Myelin-A Missing Piece of Neuroscience.Frontiers in neural circuits · 2020Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of the electrical properties of cell membranes is derived from experiments where the membrane is exposed to a perturbation (in the form of a time-dependent voltage or current change) and information is extracted from the measured output. The interpretation of such electrical recordings consists in finding an electronic equivalent that would show the same or similar response as the biological system. In general, however, there is no unique circuit configuration, which can explain a single electrical recording and the choice of an electric model for a biological system is based on complementary information (most commonly structural information) of the system investigated. Most of the electrophysiological data on cell membranes address the functional role of protein channels while assuming that the lipid matrix is an insulator with constant capacitance. However, close to their melting transition the lipid bilayers are no inert insulators. Their conductivity and their capacitance are nonlinear functions of both voltage, area and volume density. This has to be considered when interpreting electrical data. Here we show how electric data commonly interpreted as gating currents of proteins and inductance can be explained by the nonlinear dynamics of the lipid matrix itself.
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