ArticleMolecules (Basel, Switzerland)2015
Activity of Polyphenolic Compounds against Candida glabrata.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Unexplored Bioactive, Antioxidant, Antimicrobial, and Nematicidal Potential of the Flowers, Leaves, and Roots of 'Yellow Chicory' (Pharmaceuticals (Basel, Switzerland) · 2026Article
- Natural product based approaches to overcomeFrontiers in antibiotics · 2026Review
- The antibacterial activity, action mechanisms and prospects of Baicalein as an antibacterial adjuvant.World journal of microbiology & biotechnology · 2025Review
- Flavonoids, Chalcones, and Their Fluorinated Derivatives-Recent Advances in Synthesis and Potential Medical Applications.Molecules (Basel, Switzerland) · 2025Review
- Myricetin Exerts Antibiofilm Effects onJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- The Preliminary Analysis of Flavonoids in the Petals ofInternational journal of molecular sciences · 2024Article
- Influence of Major Polyphenols on the Anti-Molecules (Basel, Switzerland) · 2024Article
- Fisetin-Mediated Perturbations of Membrane Permeability and Intracellular pH inJournal of microbiology and biotechnology · 2024Article
- Mechanism of action and synergistic effect of Eugenia uniflora extract in Candida spp.PloS one · 2024Article
- Metabolic profiling ofFrontiers in plant science · 2023Article
- Naringenin and Its Derivatives-Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans.Antibiotics (Basel, Switzerland) · 2022Review
- Anti-Pharmaceutics · 2022Article
- Hesperetin-Between the Ability to Diminish Mono- and Polymicrobial Biofilms and Toxicity.Molecules (Basel, Switzerland) · 2022Article
- Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis.Microbiology spectrum · 2022Article
- HPLC-DAD analysis and antimicrobial activities of3 Biotech · 2022Article
- Myricetin Disturbs the Cell Wall Integrity and Increases the Membrane Permeability ofJournal of microbiology and biotechnology · 2022Article
- Active Flavonoids fromMolecules (Basel, Switzerland) · 2021Article
- Antifungal and Antibiofilm Activities of B-Type Oligomeric Procyanidins FromFrontiers in microbiology · 2021Article
- Flavones, Flavonols, and Glycosylated Derivatives-Impact onPharmaceuticals (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opportunistic mycoses increase the morbidity and mortality of immuno-compromised patients. Five Candida species have been shown to be responsible for 97% of worldwide cases of invasive candidiasis. Resistance of C. glabrata and C. krusei to azoles has been reported, and new, improved antifungal agents are needed. The current study was designed to evaluatethe activity of various polyphenolic compounds against Candida species. Antifungal activity was evaluated following the M27-A3 protocol of the Clinical and Laboratory Standards Institute, and antioxidant activity was determined using the DPPH assay. Myricetin and baicalein inhibited the growth of all species tested. This effect was strongest against C. glabrata, for which the minimum inhibitory concentration (MIC) value was lower than that of fluconazole. The MIC values against C. glabrata for myricitrin, luteolin, quercetin, 3-hydroxyflavone, and fisetin were similar to that of fluconazole. The antioxidant activity of all compounds was confirmed, and polyphenolic compounds with antioxidant activity had the greatest activity against C. glabrata. The structure and position of their hydroxyl groups appear to influence their activity against C. glabrata.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.