ArticleMolecules (Basel, Switzerland)2015
Phytotoxic Potential and Biological Activity of Three Synthetic Coumarin Derivatives as New Natural-Like Herbicides.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Coumarin compounds as fungicidal agents against powdery mildew and rust in cereals.Scientific reports · 2026Article
- Design, synthesis and anti-plant-bacterial (Xoc, Xac, Psa) activity of coumarins derivatives containing amide and sulfonamide moieties.BMC chemistry · 2025Article
- Effect of further substitutions at 5-, 6-, 7-, or 8-position of 3-[3-(4-methoxyphenyl)-1-hydroxyprop-2-yl]coumarin on phytotoxicity.Journal of pesticide science · 2023Article
- The Delay ofPlants (Basel, Switzerland) · 2022Article
- Deciphering chemical profiling, pharmacological responses and potential bioactive constituents ofSaudi journal of biological sciences · 2022Article
- The Steroid Saponin Protodioscin ModulatesPlants (Basel, Switzerland) · 2021Article
- Phytotoxicity, Morphological, and Metabolic Effects of the Sesquiterpenoid Nerolidol onPlants (Basel, Switzerland) · 2020Article
- Herbicidal efficacy of harzianums produced by the biofertilizer fungus, Trichoderma brevicompactum.AMB Express · 2020Article
- Allelochemical Activity of Eugenol-Derived Coumarins onPlants (Basel, Switzerland) · 2020Article
- Article
- An Aromatic Farnesyltransferase Functions in Biosynthesis of the Anti-HIV Meroterpenoid Daurichromenic Acid.Plant physiology · 2018Article
- Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction.PloS one · 2018Article
- Coumarins, Xanthones and Related Compounds.Molecules (Basel, Switzerland) · 2016Article
- Loss of Gravitropism in Farnesene-Treated Arabidopsis Is Due to Microtubule Malformations Related to Hormonal and ROS Unbalance.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coumarin is a natural compound well known for its phytotoxic potential. In the search for new herbicidal compounds to manage weeds, three synthetic derivatives bearing the coumarin scaffold (1-3), synthesized by a carbonylative organometallic approach, were in vitro assayed on germination and root growth of two noxious weeds, Amaranthus retroflexus and Echinochloa crus-galli. Moreover, the synthetic coumarins 1-3 were also in vitro assayed on seedlings growth of the model species Arabidopsis thaliana to identify the possible physiological targets. All molecules strongly affected seed germination and root growth of both weeds. Interestingly, the effects of synthetic coumarins on weed germination were higher than template natural coumarin, pointing out ED50 values ranging from 50-115 µM. Moreover, all synthetic coumarins showed a strong phytotoxic potential on both Arabidopsis shoot and root growth, causing a strong reduction in shoot fresh weight (ED50 values ≤ 60 µM), accompanied by leaf development and a decrease in pigment content. Furthermore, they caused a strong alteration in root growth (ED50 values ≤ 170 µM) and morphology with evident alterations in root tip anatomy. Taken together, our results highlight the promising potential herbicidal activity of these compounds.
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