ArticleMolecules (Basel, Switzerland)2015
Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Leaves of Perilla frutescens.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Phytochemistry and Biological Activities ofInternational journal of molecular sciences · 2025Article
- Guiling prescription attenuates hyperuricemia via multi-target regulation of uric acid metabolism, renal protection, and inflammation: insights from metabolomics and network pharmacology.Frontiers in nutrition · 2025Article
- Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations.Frontiers in endocrinology · 2024Article
- Potent Xanthine Oxidase Inhibitory Activity of Constituents ofFoods (Basel, Switzerland) · 2023Article
- Phloroglucinol Derivatives fromMolecules (Basel, Switzerland) · 2020Article
- The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.Frontiers in pharmacology · 2020Article
- An Improved Method for the Synthesis of Butein Using SOClMolecules (Basel, Switzerland) · 2019Article
- Optimization of the Extraction Conditions and Biological Evaluation ofMolecules (Basel, Switzerland) · 2018Article
- Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.Molecules (Basel, Switzerland) · 2018Article
- Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (Molecules (Basel, Switzerland) · 2018Article
- Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice.Acta pharmaceutica Sinica. B · 2018Article
- Mutagenicity, cytotoxic and antioxidant activities of Ricinus communis different parts.Chemistry Central journal · 2018Article
- Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study.BioMed research international · 2017Article
- In Vitro and In Vivo Studies onEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of Ethyl Acetate Extract of Citrus aurantium L. Dried Immature Fruits.Molecules (Basel, Switzerland) · 2016Article
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9 authors.
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Abstract
Activity-directed fractionation and purification processes were employed to identify xanthine oxidase (XO) inhibitory compounds from the leaves of Perilla frutescens. The total extract was evaluated in vitro on XO inhibitory activity and in vivo in an experimental model with potassium oxonate-induced hyperuricemia in mice which was used to evaluate anti-hyperuricemic activity. The crude extract showed expressive urate-lowering activity results. Solvent partitioning of the total extract followed by macroporous resin column chromatography of the n-butanol extract yielded four extracts and eluted parts. Among them, only the 70% ethanol eluted part of the n-butanol extract showed strong activity and therefore was subjected to separation and purification using various chromatographic techniques. Five compounds showing potent activity were identified by comparing their spectral data with literature values to be caffeic acid, vinyl caffeate, rosmarinic acid, methyl rosmarinate, and apigenin. These results indicate that pending further study, these compounds could be used as novel natural product agents for the treatment of hyperuricemia.
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