Evidence map›Paper›PMID 26425551›Full record

ArticleBioMed research international2015

Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma.

Maria R Ambrosio, Bruno J Rocca, Aurora Barone, Monica Onorati, Lucia Mundo, Filippo Crivelli, Franca Di Nuovo, Giulia De Falco, Maria T del Vecchio, Sergio A Tripodi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Maria R AmbrosioSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
Bruno J RoccaSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy ; Section of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Piazzale Borella 1, 21047 Saronno, Italy.
Aurora BaroneSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
Monica OnoratiSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy ; Section of Pathology, Azienda Ospedaliera, "G. Salvini", Viale C. Forlanini 121, 20024 Garbagnate Milanese, Italy.
Lucia MundoSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
Filippo CrivelliSection of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Piazzale Borella 1, 21047 Saronno, Italy.
Franca Di NuovoSection of Pathology, Azienda Ospedaliera, "G. Salvini", Viale C. Forlanini 121, 20024 Garbagnate Milanese, Italy.
Giulia De FalcoSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy ; School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E14NS, UK.
Maria T del VecchioDepartment of Medicine, Science and Neurosciences, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
Sergio A TripodiSection of Pathology, Azienda Ospedaliera Universitaria Senese, Viale Bracci 16, 53100 Siena, Italy.
Piero TosiSection of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
University of Siena · ITAzienda Ospedaliera San Camillo-Forlanini · ITOspedale di Circolo di Busto Arsizio · ITAzienda Ospedaliera Universitaria Senese · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translationally controlled tumor protein is a multifaceted protein involved in several physiological and biological functions. Its expression in normal kidney and in renal carcinomas, once corroborated by functional data, may add elements to elucidate renal physiology and carcinogenesis. In this study, translationally controlled tumor protein expression was evaluated by quantitative real time polymerase chain reaction and western blotting, and its localization was examined by immunohistochemistry on 84 nephrectomies for cancer. In normal kidney protein expression was found in the cytoplasm of proximal and distal tubular cells, in cells of the thick segment of the loop of Henle, and in urothelial cells of the pelvis. It was also detectable in cells of renal carcinoma with different pattern of localization (membranous and cytoplasmic) depending on tumor histotype. Our data may suggest an involvement of translationally controlled tumor protein in normal physiology and carcinogenesis. However, functional in vitro and in vivo studies are needed to verify this hypothesis.

Indexed as

Biomarkers, TumorBlotting, WesternCarcinoma, Renal CellGene Expression Regulation, NeoplasticHumansImmunohistochemistryKidneyKidney NeoplasmsReal-Time Polymerase Chain ReactionStaining and LabelingTumor Protein, Translationally-Controlled 1Biomarkers, TumorTumor Protein, Translationally-Controlled 1

Identifiers

PMID26425551
PMCPMC4573619
OpenAlexW1567361678

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.