ReviewAging and disease2015
Mechanisms of Muscle Denervation in Aging: Insights from a Mouse Model of Amyotrophic Lateral Sclerosis.
Review in Aging and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- CRISPR-Cas technologies in neurodegenerative disorders: mechanistic insights, therapeutic potential, and translational challenges.Frontiers in neurology · 2025Review
- Motionless volumetric structured light sheet microscopy.Biomedical optics express · 2023Article
- CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders.Molecular neurobiology · 2022Review
- Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline.GeroScience · 2021Article
- Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Age-Related Decline of Sensorimotor Integration Influences Resting-State Functional Brain Connectivity.Brain sciences · 2020Article
- Rodent Model of Muscular Atrophy for Sarcopenia Study.Journal of bone metabolism · 2020Review
- Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions.Frontiers in molecular neuroscience · 2020Review
- Redox responses in skeletal muscle following denervation.Redox biology · 2019Article
- Review
- Review
- Increase in phospholamban content in mouse skeletal muscle after denervation.Journal of muscle research and cell motility · 2018Article
- SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.Aging cell · 2018Article
- NMJ maintenance and repair in aging.Current opinion in physiology · 2018Article
- Bridging the gap: large animal models in neurodegenerative research.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Review
- Multiple roles of integrin-α3 at the neuromuscular junction.Journal of cell science · 2017Article
- Overexpression of thioredoxin-2 attenuates age-related muscle loss by suppressing mitochondrial oxidative stress and apoptosis.JCSM rapid communicationsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle denervation at the neuromuscular junction (NMJ) is thought to be a contributing factor in age-related muscle weakness. Therefore, understanding the mechanisms that modulate NMJ innervation is a key to developing therapies to combat age-related muscle weakness affecting the elderly. Two mouse models, one lacking the Cu/Zn superoxide dismutase (SOD1) gene and another harboring the transgenic mutant human SOD1 gene, display progressive changes at the NMJ, including muscle endplate fragmentation, nerve terminal sprouting, and denervation. These changes at the NMJ share many of the common features observed in the NMJs of aged mice. In this review, research findings demonstrating the effects of PGC-1α, IGF-1, GDNF, MyoD, myogenin, and miR-206 on NMJ innervation patterns in the G93A SOD1 mice will be highlighted in the context of age-related muscle denervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.