ReviewBeilstein journal of organic chemistry2015
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.
Review in Beilstein journal of organic chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Practical Microwave-Assisted Recirculated Flow Esterification at Atmospheric Pressure.ACS omega · 2026Article
- Mechanistic Insights into Novel Water-Mediated Sustainable Synthesis of Dicarboxylic Acids in Green Solvent Systems.ACS omega · 2026Article
- The Impact of Continuous Flow Technology and Collaboration between Academia and Industry.JACS Au · 2026Review
- A continuous flow process for the Ireland-Claisen rearrangement.RSC advances · 2025Article
- Article
- Automation and machine learning augmented by large language models in a catalysis study.Chemical science · 2024Review
- Exploring the Solubility Limits of Edaravone in Neat Solvents and Binary Mixtures: Experimental and Machine Learning Study.Molecules (Basel, Switzerland) · 2023Article
- From Batch to the Semi-Continuous Flow Hydrogenation ofPharmaceutics · 2023Article
- Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode.International journal of molecular sciences · 2023Article
- Towards Antibiotic Synthesis in Continuous-Flow Processes.Molecules (Basel, Switzerland) · 2023Review
- Harnessing a Continuous-Flow Persulfuric Acid Generator for Direct Oxidative Aldehyde Esterifications.ChemSusChem · 2023Article
- Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients.Molecules (Basel, Switzerland) · 2022Review
- Understanding flow chemistry for the production of active pharmaceutical ingredients.iScience · 2022Review
- "Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry.Molecules (Basel, Switzerland) · 2022Review
- Scaled up and telescoped synthesis of propofol under continuous-flow conditions.Journal of flow chemistry · 2022Article
- Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates.Green chemistry : an international journal and green chemistry resource : GC · 2021Review
- Segmented Flow Processes to Overcome Hurdles of Whole-Cell Biocatalysis in the Presence of Organic Solvents.Angewandte Chemie (International ed. in English) · 2021Article
- Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow*.Angewandte Chemie (International ed. in English) · 2021Article
- C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative.Molecules (Basel, Switzerland) · 2021Article
- A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries.Beilstein journal of organic chemistry · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.