Evidence map›Paper›PMID 26424751›Full record

SynthesisCarcinogenesis2015

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.

Kate Lawrenson, Edwin S Iversen, Jonathan Tyrer, Rachel Palmieri Weber, Patrick Concannon, Dennis J Hazelett, Qiyuan Li, Jeffrey R Marks, Andrew Berchuck, Janet M Lee and 148 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Deciphering the multifaceted role ofFrontiers in immunology · 2025
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  4. Article
  5. Review
  6. Article
  7. Annals of medicine · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Frontiers in oncology · 2019
    Article
  16. Inherited pancreatic cancer.Chinese clinical oncology · 2017
    Review
  17. Article
  18. Review
  19. Article
  20. Significant association of theOncoTargets and therapy · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

158 authors at 20 institutions in 15 countries.

Kate LawrensonPresent address: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA and.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, NC 27708, USA.
Jonathan TyrerDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Patrick ConcannonGenetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Dennis J HazelettDepartments of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA.
Qiyuan LiMedical School, Xiamen University, Xiamen 361000, China.
Jeffrey R MarksDepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
Janet M Lee
Katja K H AbenDepartment for Health Evidence, Nijmegen 6500 HB, The Netherlands, Comprehensive Cancer Center, Utrecht 3542 EG, The Netherlands.
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Natalia AntonenkovaByelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk 223052, Belarus.
Australian Cancer Study (Ovarian Cancer)
Australian Ovarian Cancer Study Group
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Yukie BeanDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway.
Natalia BogdanovaGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council of Victoria, Melbourne Victoria 3004, Australia.
Ralf ButzowDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland, Department of Pathology, Helsinki University Central Hospital, Helsinki 00029, Finland.
Ian G CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia, Department of Pathology, University of Melbourne, Parkville, Victoria 3002, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3002, Australia.
Karen CartyCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane Queensland 4029, Australia.
Ann ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, FL 33612, USA.
Zhihua ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, FL 33612, USA.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Daniel W CramerHarvard School of Public Health, Boston, MA 02115, USA, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Cezary CybulskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Joanna Plisiecka-HalasaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Joe DennisDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Ed DicksDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Jennifer A DohertyDepartment of Community and Family Medicine, Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Andreas du BoisGenetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany.
Diana EcclesWessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, UK.
Douglas T EastonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Robert P EdwardsWessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, UK, Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15222, USA.
Ursula EilberDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles CA 90095, USA.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Yu-Tang GaoShanghai Cancer Institute, Shanghai 200032, China.
Aleksandra Gentry-MaharajDepartment of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
Graham G GilesCancer Epidemiology Centre, Cancer Council of Victoria, Melbourne Victoria 3004, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria 3010, Australia.
Rosalind GlasspoolCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Ellen L GoodeDepartment of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen 45136, Germany, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany.
Hanis Nazihah HasmadCancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500, Malaysia.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen 45136, Germany, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Peter HillemannsDepartments of Obstetrics and Gynaecology, Hannover Medical School, Hannover 30625, Germany.
Estrid HogdallInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen DK-2100, Denmark, Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen DK-2100, Denmark.
Claus HogdallGyn Clinic, Rigshospitalet, University of Copenhagen DK-2100, Denmark.
Satoyo HosonoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
James PaulCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Susanne Kruger KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark.
Linda E KelemenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Melissa KellarDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Joseph L KelleyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15222, USA.
Lambertus A KiemeneyDepartment for Health Evidence and Department of Urology, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands.
Camilla KrakstadDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway.
Diether LambrechtsVesalius Research Center, VIB, Leuven 3000, Belgium, Laboratory for Translational Genetics, Department of Oncology, University of Leuven 3000, Belgium.
Sandrina LambrechtsDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
Alice W Lee
Rikki CanniotoDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Karen LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Lene LundvallGyn Clinic, Rigshospitalet, University of Copenhagen DK-2100, Denmark.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan.
Valerie McGuireDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
John R McLaughlinProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland.
Iain McNeishInstitute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow G61 1QH, UK.
Usha MenonDepartment of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
Francesmary ModugnoOvarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15222, USA, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15222, USA, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15222, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15222, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Steven A NarodWomen's College Research Institute, Toronto, Ontario M5G 1N8, Canada.
Lotte NedergaardDepartment of Pathology, Rigshospitalet, University of Copenhagen DK-2100, Denmark.
Roberta B NessThe University of Texas School of Public Health, Houston, TX 77225, USA.
Mat Adenan Noor AzmiDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia.
Kunle OdunsiDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Sandra OrsulicWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Celeste L PearceDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
Tanja PejovicDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland.
Jennifer Permuth-WeyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Catherine M PhelanDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Malcolm C PikeDepartment of Statistical Science, Duke University, Durham, NC 27708, USA, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Susan J Ramus
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA.
Barry RosenDepartment of Gynecologic-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1X6, Canada.
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA.
Joseph H RothsteinDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany.
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena D-07743, Germany.
Iwona K RzepeckaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway.
Agnieszka BudzilowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Thomas A SellersDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii 96826, USA.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Honglin SongDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Parkville, Victoria 3002, Australia.
Lara SuchestonCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Ingvild L TangenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway.
Soo-Hwang TeoDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia.
Kathryn L TerryHarvard School of Public Health, Boston, MA 02115, USA, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Agnieszka TimorekDepartment of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw 03-242, Poland.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Els Van NieuwenhuysenDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium.
Ignace VergoteDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium.
Robert A VierkantDepartment of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA.
Shan Wang-GohrkeDepartment of Obstetrics and Gynecology, University of Ulm, Ulm 89075, Germany.
Christine WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kristine G WicklundDepartment of Epidemiology, University of Washington, Seattle, WA 98109, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii 96826, USA.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia, University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Anna H Wu
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Argyrios ZiogasComprehensive Cancer Center, Utrecht 3542 EG, The Netherlands.
Gerhard A CoetzeeDepartments of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA.
Matthew L FreedmanDepartment of Medical Oncology, 02115, Dana-Farber Cancer Institute, Boston, MA, USA.
Alvaro N A MonteiroCancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA and.
Joanna Moes-SosnowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Jolanta KupryjanczykDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Paul D PharoahDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK.
Simon A GaytherPresent address: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Joellen M SchildkrautDepartment of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA, Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC 27710, USA, jms2yf@virginia.edu.
Cedars-Sinai Medical Center · USUniversity of Cambridge · GBBrigham and Women's Hospital · USUniversity of Southern California · USMemorial Sloan Kettering Cancer Center · USUniversity of Copenhagen · DKUniversity of Helsinki · FIGerman Cancer Research Center · DEHaukeland University Hospital · NORadboud University Nijmegen · NLThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USUniversity Malaya Medical Centre · MYBC Cancer Agency · CABeatson West of Scotland Cancer Centre · GBDuke Medical Center · USHelios Dr. Horst Schmidt Kliniken Wiesbaden · DERoswell Park Comprehensive Cancer Center · USVanderbilt University · USCancer Council Victoria · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
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6 · The paper itself

Abstract

Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide polymorphisms (SNPs) and indels] in DNA repair genes and EOC risk. We genotyped 2896 common variants at 143 gene loci in DNA samples from 15 397 patients with invasive EOC and controls. We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001). The strongest risk association was for CHEK2 SNP rs17507066 with serous EOC (P = 4.74 x 10(-7)). Additional genotyping and imputation of genotypes from the 1000 genomes project identified a slightly more significant association for CHEK2 SNP rs6005807 (r (2) with rs17507066 = 0.84, odds ratio (OR) 1.17, 95% CI 1.11-1.24, P = 1.1×10(-7)). We identified 293 variants in the region with likelihood ratios of less than 1:100 for representing the causal variant. Functional annotation identified 25 candidate SNPs that alter transcription factor binding sites within regulatory elements active in EOC precursor tissues. In The Cancer Genome Atlas dataset, CHEK2 gene expression was significantly higher in primary EOCs compared to normal fallopian tube tissues (P = 3.72×10(-8)). We also identified an association between genotypes of the candidate causal SNP rs12166475 (r (2) = 0.99 with rs6005807) and CHEK2 expression (P = 2.70×10(-8)). These data suggest that common variants at 22q12.1 are associated with risk of serous EOC and CHEK2 as a plausible target susceptibility gene.

Indexed as

Carcinoma, Ovarian EpithelialCase-Control StudiesCheckpoint Kinase 2FemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansNeoplasms, Glandular and EpithelialOvarian NeoplasmsPolymorphism, Single NucleotideQuantitative Trait LociRisk FactorsCheckpoint Kinase 2CHEK2 protein, human

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PMID26424751
PMCPMC4635670
OpenAlexW2263949224

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