ArticleScientific reports2015
Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Tuning Hyaluronic Acid Microstructures by Engineered Amphiphilicity: From Dynamically Cross-Linked Gels to Multilayered Nanoparticles.ACS applied materials & interfaces · 2025Article
- A mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra-Articular Space.Advanced healthcare materials · 2025Article
- Polydeoxynucleotide-Loaded Visible Light Photo-Crosslinked Gelatin Methacrylate Hydrogel: Approach to Accelerating Cartilage Regeneration.Gels (Basel, Switzerland) · 2025Article
- Drug retention after intradiscal administration.Drug delivery · 2024Article
- Multifunctional nanoparticle-mediated combining therapy for human diseases.Signal transduction and targeted therapy · 2024Review
- Multifunctional thermo-sensitive hydrogel for modulating the microenvironment in Osteoarthritis by polarizing macrophages and scavenging RONS.Journal of nanobiotechnology · 2022Article
- Therapeutic effect of intra-articular injected 3'-sialyllactose on a minipig model of rheumatoid arthritis induced by collagen.Laboratory animal research · 2022Article
- Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation.Advanced therapeutics · 2022Article
- Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis.Hereditas · 2021Article
- Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-International journal of molecular sciences · 2021Article
- Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems.Pharmaceutics · 2021Review
- Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis.Journal of nanobiotechnology · 2020Article
- An Injectable Click-Crosslinked Hydrogel that Prolongs Dexamethasone Release from Dexamethasone-Loaded Microspheres.Pharmaceutics · 2019Article
- NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis.International journal of molecular sciences · 2019Article
- Enhanced Therapeutic Effect of RGD-Modified Polymeric Micelles Loaded With Low-Dose Methotrexate and Nimesulide on Rheumatoid Arthritis.Theranostics · 2019Article
- Intra-Articular Formulation of GE11-PLGA Conjugate-Based NPs for Dexamethasone Selective Targeting-In Vitro Evaluation.International journal of molecular sciences · 2018Article
- Disease-Triggered Drug Release Effectively Prevents Acute Inflammatory Flare-Ups, Achieving Reduced Dosing.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Towards an arthritis flare-responsive drug delivery system.Nature communications · 2018Article
- Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
The effectiveness of systemic rheumatoid arthritis (RA) treatments is limited by difficulties in achieving therapeutic doses within articular joints. We evaluated the ability of intra-articular administration of injectable formulations to synergistically enhance repair of RA joints. Methotrexate-loaded hyaluronic acid (Met-HA), dexamethasone-loaded microcapsules (Dex-M), and Dex-M dispersed inside Met-HA were prepared as viscous emulsions and injected into articular joints using a needle to form a drug depot. By near-infrared (NIR) fluorescence imaging, we confirmed the local release of NIR from the depot injected into the articular joint over an extended period. In comparison with the subjects treated with Met-HA or Dex-M alone, subjects treated simultaneously with Met-HA and Dex-M exhibited faster and more significant RA repair. Collectively, these results indicated that the drug depot formed after intra-articular injection of Met-HA/Dex-M induced long-lasting drug release and allowed Met and Dex to effectively act in the articular joint, resulting in enhanced RA repair.
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