Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia.

Abhishek Sinha, Atrayee Ray, Sandipan Ganguly, Shubhra Ghosh Dastidar, Srimonti Sarkar

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Article in Biology direct, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors at 2 institutions in 1 country.

Abhishek SinhaDepartment of Biochemistry, Bose Institute, P-1/12 CIT Road, Scheme VII M, Kolkata, 700054,, West Bengal, India. abhishek.boseinst.84@gmail.com.

Atrayee RayDepartment of Biochemistry, Bose Institute, P-1/12 CIT Road, Scheme VII M, Kolkata, 700054,, West Bengal, India. atrayeeray@mail.jcbose.ac.in.

Sandipan GangulyMolecular Parasitology, National Institute of Cholera and Enteric Diseases, P-33, C.I.T Road, Scheme XM, Kolkata, 700010,, West Bengal, India. gangulys@icmr.org.in.

Shubhra Ghosh DastidarBioinformatics Center, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, 700054,, West Bengal, India. sgd@jcbose.ac.in.

Srimonti SarkarDepartment of Biochemistry, Bose Institute, P-1/12 CIT Road, Scheme VII M, Kolkata, 700054,, West Bengal, India. srimonti@jcbose.ac.in.

Bose Institute · INNational Institute of Cholera and Enteric Diseases · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between the ribosome and the endoplasmic reticulum-located Sec61 protein translocon is mediated through an arginine residue of Sec61α, which is conserved in all prokaryotic and eukaryotic orthologues characterized to date. Using in silico approaches we report that instead of arginine, this ribosome-interaction function is most likely discharged by a lysine residue in the protist Giardia lamblia. This functional substitution of the R with a K in GlSec61α may have taken place to accommodate a G-rich rRNA.

Indexed as

Computer SimulationEndoplasmic ReticulumGiardia lambliaLysineMembrane ProteinsProtozoan ProteinsRibosomesSEC Translocation ChannelsLysineMembrane ProteinsProtozoan ProteinsSEC Translocation Channels

Identifiers

PMID26424409

DOI10.1186/s13062-015-0087-0

PMCPMC4588681

OpenAlexW2133759396

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