ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2015
Comparison of Heart Rate and Blood Pressure with Toe Pinch and Bispectral Index for Monitoring the Depth of Anesthesia in Piglets.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Quantitative Variables Derived from the Electroencephalographic Signal to Assess Depth of Anaesthesia in Animals: A Narrative Review.Animals : an open access journal from MDPI · 2025Review
- Distinct Serum Glial Fibrillary Acidic Protein and Neurofilament Light Time-Courses After Rapid Head Rotations.Journal of neurotrauma · 2024Article
- The nociceptive withdrawal reflex during spinal analgesia in pigs undergoing veno-arterial extracorporeal membrane oxygenation: a prospective observational study.Frontiers in veterinary science · 2024Article
- SedlineAnimals : an open access journal from MDPI · 2023Article
- Article
- Correlation of Sedline-generated variables and clinical signs with anaesthetic depth in experimental pigs receiving propofol.PloS one · 2022Article
- Machine learning reveals interhemispheric somatosensory coherence as indicator of anesthetic depth.Frontiers in neuroinformatics · 2022Article
- Alfaxalone-Xylazine Anesthesia in Laboratory Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Clonidine Protects Against Neurotoxicity Induced by Sevoflurane Through NF-κB Signaling Inhibition and Proinflammatory Cytokine Release in Rats.Journal of molecular neuroscience : MN · 2018Article
- Comparison of Aqueous and Alcohol-based Agents for Presurgical Skin Preparation Methods in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Cardiopulmonary Effects of a Partial Intravenous Anesthesia Technique for Laboratory Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Determining depth of anesthesia (DOA) is a clinical challenge in veterinary medicine, yet it is critical for the appropriate oversight of animals involved in potentially painful experimental procedures. Here, we investigated various parameters used to monitor conscious awareness during surgical procedures and refined the application of noxious stimuli to anesthetized animals. Specifically we used a common stimulus, a compressive toe pinch (TP), to determine physiologic changes that accompanied a positive or negative motion response in isoflurane-anesthetized piglets. A positive response was defined as any reflexive withdrawal, whereas a negative response was defined as the absence of motion after stimulation. We also assessed the utility of the bispectral index (BIS) for its ability to predict a motion response to TP. The average of BIS values over 1 min (BISmean) was recorded before and after TP. In piglets with a positive response to TP, heart rate (HR), but not blood pressure (BP), increased significantly, but receiver operating characteristic (ROC) analysis revealed that HR was not a sensitive, specific predictor of TP motion response. Both before and after TP, BISmean was a strong predictor of a positive motion response. We conclude that HR and noninvasive BP changes are not clinically reliable indicators of anesthetic depth when assessed immediately after a peripherally applied compressive force as an indicator stimulus; however, BISmean and response TP are acceptable for assessing DOA in piglets maintained under isoflurane anesthesia.
Indexed as
Identifiers
26424252PMC4587622W2469628556What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.