Evidence map›Paper›PMID 26424095›Full record

ArticleInflammation2016

Treatment of CIA Mice with FGF21 Down-regulates TH17-IL-17 Axis.

Si-Ming Li, Yin-Hang Yu, Lu Li, Wen-Fei Wang, De-Shan Li

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Mechanism of fibroblast growth factor 21 in cardiac remodeling.Frontiers in cardiovascular medicine · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Metformin as a Treatment Strategy for Sjögren's Syndrome.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
  10. Aging · 2020
    Article
  11. Article
  12. Review
  13. The FGF metabolic axis.Frontiers of medicine · 2019
    Review
  14. The Adipokine Network in Rheumatic Joint Diseases.International journal of molecular sciences · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Si-Ming LiHarbin University of Commerce, No. 1 Xuehai Street Songbei Distric, 150028, Harbin, Heilongjiang, China. 1456382154@qq.com.
Yin-Hang YuSchool of Life Science, Northeast Agricultural University, No. 59 Mucai Street Xiangfang Distric, 150030, Harbin, Heilongjiang, China.
Lu LiSchool of Life Science, Northeast Agricultural University, No. 59 Mucai Street Xiangfang Distric, 150030, Harbin, Heilongjiang, China.
Wen-Fei WangSchool of Life Science, Northeast Agricultural University, No. 59 Mucai Street Xiangfang Distric, 150030, Harbin, Heilongjiang, China.
De-Shan LiSchool of Life Science, Northeast Agricultural University, No. 59 Mucai Street Xiangfang Distric, 150030, Harbin, Heilongjiang, China. deshanli@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, FGF21 was reported to play an important role in anti-inflammation. The aim of the study is to explore the mechanism for FGF21 alleviating inflammation of CIA. CIA mice were injected with FGF21 once a day for 28 days after first booster immunization. The results showed that FGF21 alleviates arthritis severity and decreases serum anti-CII antibodies levels in CIA mice. Compared with CIA model, the number of the splenic TH17 cells was significantly decreased in FGF21-treated mice. FGF21 treatment reduced the mRNA expression of IL-17, TNF-α, IL-1β, IL-6, IL-8, and MMP3 and increased level of IL-10 in the spleen tissue. The expression of STAT3 and phosphorylated STAT3 was suppressed in FGF21-treated group. The mRNA expression of RORγt and IL-23 also decreased. In conclusion, these findings suggest that the beneficial effects of FGF21 on CIA mice were achieved by down-regulating Th17-IL-17 axis through STAT3/RORγt pathway. Modulating of Th17-mediated inflammatory response may be one of the mechanisms for FGF21 attenuating inflammation in CIA.

Indexed as

AnimalsArthritis, ExperimentalDown-RegulationFibroblast Growth FactorsInflammationInterleukin-10Interleukin-17Interleukin-1betaInterleukin-23 Subunit p19Interleukin-6Interleukin-8MaleMatrix Metalloproteinase 3MiceMice, Inbred DBANuclear Receptor Subfamily 1, Group F, Member 3fibroblast growth factor 21Fibroblast Growth FactorsIL10 protein, mouseIl17a protein, mouseIL1B protein, mouseIl23a protein, mouseInterleukin-10Interleukin-17Interleukin-1betaInterleukin-23 Subunit p19Interleukin-6Interleukin-8Matrix Metalloproteinase 3Mmp3 protein, mouseNuclear Receptor Subfamily 1, Group F, Member 3RNA, MessengerStat3 protein, mouseSTAT3 Transcription FactorTumor Necrosis Factor-alphaCIA micefibroblast growth factor 21(FGF21)IL-17TH17 cell

Identifiers

PMID26424095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.