ArticleProceedings. Biological sciences2015
Dopamine is a key regulator in the signalling pathway underlying predator-induced defences in Daphnia.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Ontogenetic Sequence of Differential Gene Expression in Predator-Induced Daphnia pulex.Molecular ecology · 2026Article
- Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future.Heredity · 2025Review
- Article
- Dopamine mediates the pea aphid wing plasticity.Biology letters · 2023Article
- Distinct cell proliferation patterns underlying the development of defensive crests inHeliyon · 2022Article
- Maternal dopamine exposure provides offspring starvation resistance inEcology and evolution · 2022Article
- Pharmacological modulation of fish-induced depth selection in D. magna: the role of cholinergic and GABAergic signalling.Scientific reports · 2021Article
- Antipredator phenotype in crucian carp altered by a psychoactive drug.Ecology and evolution · 2021Article
- Brain volume increase and neuronal plasticity underly predator-induced morphological defense expression in Daphnia longicephala.Scientific reports · 2021Article
- Current Knowledge on Microviridin from Cyanobacteria.Marine drugs · 2021Review
- Dopamine mediates life-history responses to food abundance inProceedings. Biological sciences · 2020Article
- Kairomone-like activity of bile and bile components: A step towards revealing the chemical nature of fish kairomone.Scientific reports · 2020Article
- Transcriptome sequencing of a keystone aquatic herbivore yields insights on the temperature-dependent metabolism of essential lipids.BMC genomics · 2019Article
- Cyanobacterial Neurotoxin Beta-Methyl-Amino-l-Alanine Affects Dopaminergic Neurons in Optic Ganglia and Brain ofToxins · 2018Article
- Identification of Chaoborus kairomone chemicals that induce defences in Daphnia.Nature chemical biology · 2018Article
- Pattern of DNA Methylation in Daphnia: Evolutionary Perspective.Genome biology and evolution · 2018Article
- Comparative Transcriptome Analysis for Understanding Predator-Induced Polyphenism in the Water FleaInternational journal of molecular sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The waterflea Daphnia is a model to investigate the genetic basis of phenotypic plasticity resulting from one differentially expressed genome. Daphnia develops adaptive phenotypes (e.g. morphological defences) thwarting predators, based on chemical predator cue perception. To understand the genomic basis of phenotypic plasticity, the description of the precedent cellular and neuronal mechanisms is fundamental. However, key regulators remain unknown. All neuronal and endocrine stimulants were able to modulate but not induce defences, indicating a pathway of interlinked steps. A candidate able to link neuronal with endocrine responses is the multi-functional amine dopamine. We here tested its involvement in trait formation in Daphnia pulex and Daphnia longicephala using an induction assay composed of predator cues combined with dopaminergic and cholinergic stimulants. The mere application of both stimulants was sufficient to induce morphological defences. We determined dopamine localization in cells found in close association with the defensive trait. These cells serve as centres controlling divergent morphologies. As a mitogen and sclerotization agent, we anticipate that dopamine is involved in proliferation and structural formation of morphological defences. Furthermore, dopamine pathways appear to be interconnected with endocrine pathways, and control juvenile hormone and ecdysone levels. In conclusion, dopamine is suggested as a key regulator of phenotypic plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.