ArticlePhysiology & behavior2015
Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events.Journal of mental health & clinical psychology · 2024Article
- Applying behavioral economics-based approaches to examine the effects of liquid sucrose consumption on motivation.Appetite · 2023Article
- Cocaine-induced plasticity, motivation, and cue responsivity do not differ in obesity-prone vs obesity-resistant rats; implications for food addiction.Psychopharmacology · 2023Article
- D1 and D2 neurons in the nucleus accumbens enable positive and negative control over sugar intake in mice.Cell reports · 2023Article
- Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.Journal of neurochemistry · 2023Article
- Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats.Obesity (Silver Spring, Md.) · 2023Article
- Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sex specific effects of "junk-food" diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- Nucleus Accumbens Functional Connectivity with the Frontoparietal Network Predicts Subsequent Change in Body Mass Index for American Children.Brain sciences · 2020Article
- Sex and region-specific effects of high fat diet on PNNs in obesity susceptible rats.Physiology & behavior · 2020Article
- Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation.Neurobiology of stress · 2020Article
- Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs.Current pharmaceutical design · 2020Article
- Effects of the estrous cycle and ovarian hormones on cue-triggered motivation and intrinsic excitability of medium spiny neurons in the Nucleus Accumbens core of female rats.Hormones and behavior · 2019Article
- Eating "junk food" has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible versus -resistant rats.Journal of neurophysiology · 2019Article
- Enhanced anxiety-like behavior emerges with weight gain in male and female obesity-susceptible rats.Behavioural brain research · 2019Article
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Authors and funding
5 authors.
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Abstract
Obesity is a significant problem in the United States, with roughly one third of adults having a body mass index (BMI) over thirty. Recent evidence from human studies suggests that pre-existing differences in the function of mesolimbic circuits that mediate motivational processes may promote obesity and hamper weight loss. However, few preclinical studies have examined pre-existing neurobehavioral differences related to the function of mesolimbic systems in models of individual susceptibility to obesity. Here, we used selectively bred obesity-prone and obesity-resistant rats to examine 1) the effect of a novel "junk-food" diet on the development of obesity and metabolic dysfunction, 2) over-consumption of "junk-food" in a free access procedure, 3) motivation for food using instrumental procedures, and 4) cocaine-induced locomotor activity as an index of general mesolimbic function. As expected, eating a sugary, fatty, "junk-food" diet exacerbated weight gain and increased fasted insulin levels only in obesity-prone rats. In addition, obesity-prone rats continued to over-consume junk-food during discrete access testing, even when this same food was freely available in the home cage. Furthermore, when asked to press a lever to obtain food in an instrumental task, rates of responding were enhanced in obesity-prone versus obesity-resistant rats. Finally, obesity-prone rats showed a stronger locomotor response to 15 mg/kg cocaine compared to obesity-resistant rats prior to any diet manipulation. This enhanced sensitivity to this dose of cocaine is indicative of basal differences in the function of mesolimbic circuits in obesity-prone rats. We speculate that pre-existing differences in motivational systems may contribute to over-consumption and enhanced motivation in susceptible individuals.
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