Evidence map›Paper›PMID 26423675›Full record

SynthesisWorld journal of surgery2016

Mesh Location in Open Ventral Hernia Repair: A Systematic Review and Network Meta-analysis.

Julie L Holihan, Duyen H Nguyen, Mylan T Nguyen, Jiandi Mo, Lillian S Kao, Mike K Liang

Registry-linked trialAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07720154 (Sac-Flap Peritonealization of Mesh in Bony-Edged Ventral Hernias), which is not on this map. Cited by 153 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07720154 narecruitingnot on this mapstarted 2026, after this paper: background citation

Sac-Flap Peritonealization of Mesh in Bony-Edged Ventral Hernias: A Randomized Controlled Trial

TypeinterventionalSponsorMinia UniversityRan2026 to 2028Enrolled180ConditionsIncisional Hernia, Abdominal Hernia, Complex Ventral Hernia, Surgical Site InfectionArmsSac-flap peritonealization of the mesh, Retromuscular (sublay) synthetic mesh repair
3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Drain placement in retromuscular ventral hernia repair: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2023
    Pooled it
  8. Pooled it
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  10. Systematic review of transversus abdominis release in complex abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2019
    Pooled it
  11. Pooled it
  12. The Treatment of Incisional Hernia.Deutsches Arzteblatt international · 2018
    Pooled it
  13. Trial
  14. Trial
  15. Trial
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  17. Review
  18. Article
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  20. Review

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julie L HolihanDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Julie.L.Holihan@uth.tmc.edu.
Duyen H NguyenDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Dhnguyen.06@gmail.com.
Mylan T NguyenDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Mylan.thi.nguyen@gmail.com.
Jiandi MoDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Mojiandi@gmail.com.
Lillian S KaoDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Lillian.S.Kao@uth.tmc.edu.
Mike K LiangDepartment of General Surgery, University of Texas Health Science Center, 6431 Fannin St, Houston, TX, 77030, USA. Mike.Liang@uth.tmc.edu.

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
NCATS NIH HHS KL2 TR000370NCATS NIH HHS UL1 TR000371
6 · The paper itself

Abstract

There is no consensus on the ideal location for mesh placement in open ventral hernia repair (OVHR). We aim to identify the mesh location associated with the lowest rate of recurrence following OVHR using a systematic review and meta-analysis. A search was performed for studies comparing at least two of four locations for mesh placement during OVHR (onlay, inlay, sublay, and underlay). Outcomes assessed were hernia recurrence and surgical site infection (SSI). Pairwise meta-analysis was performed to compare all direct treatment of mesh locations. A multiple treatment meta-analysis was performed to compare all mesh locations in the Bayesian framework. Sensitivity analyses were planned for the following: studies with a low risk of bias, incisional hernias, by hernia size, and by mesh type (synthetic or biologic). Twenty-one studies were identified (n = 5,891). Sublay placement of mesh was associated with the lowest risk for recurrence [OR 0.218 (95% CI 0.06-0.47)] and was the best of the four treatment modalities assessed [Prob (best) = 94.2%]. Sublay was also associated with the lowest risk for SSI [OR 0.449 (95% CI 0.12-1.16)] and was the best of the 4 treatment modalities assessed [Prob (best) = 77.3%]. When only assessing studies at low risk of bias, of incisional hernias, and using synthetic mesh, the probability that sublay had the lowest rate of recurrence and SSI was high. Sublay mesh location has lower complication rates than other mesh locations. While additional randomized controlled trials are needed to validate these findings, this network meta-analysis suggests the probability of sublay being the best location for mesh placement is high.

Indexed as

Surgical MeshHernia, VentralHerniorrhaphyHumansRecurrence

Identifiers

PMID26423675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.