Evidence map›Paper›PMID 26423655›Full record

ArticleDrug delivery and translational research2015

Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications.

Chase S Linsley, Viola Y Quach, Gaurav Agrawal, Elyse Hartnett, Benjamin M Wu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery and translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 34 citations in OpenAlex.

  1. Photocatalyzed elaboration of antibody-based bioconjugates.Beilstein journal of organic chemistry · 2025
    Article
  2. Light-responsive biomaterials for ocular drug delivery.Drug delivery and translational research · 2023
    Review
  3. Preparation of photothermal palmitic acid/cholesterol liposomes.Journal of biomedical materials research. Part B, Applied biomaterials · 2019
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chase S LinsleyDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V., P.O. Box: 951600, Los Angeles, CA, 90095-1600, USA.
Viola Y QuachDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V., P.O. Box: 951600, Los Angeles, CA, 90095-1600, USA.
Gaurav AgrawalDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V., P.O. Box: 951600, Los Angeles, CA, 90095-1600, USA.
Elyse HartnettDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V., P.O. Box: 951600, Los Angeles, CA, 90095-1600, USA.
Benjamin M WuDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V., P.O. Box: 951600, Los Angeles, CA, 90095-1600, USA. benwu@ucla.edu.
University of California, Los Angeles · US

Funding

Growth factor delivery using light-sensitive fibrin to treat chronic woundsR21AR064437 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TAWIL, BILL, WU, BENJAMIN M · 2014 to 2015
$359k
NIAMS NIH HHS R21 AR064437
6 · The paper itself

Abstract

The need for temporal-spatial control over the release of biologically active molecules has motivated efforts to engineer novel drug delivery-on-demand strategies actuated via light irradiation. Many systems, however, have been limited to in vitro proof-of-concept due to biocompatibility issues with the photo-responsive moieties or the light wavelength, intensity, and duration. To overcome these limitations, this paper describes a light actuated drug delivery-on-demand strategy that uses visible and near-infrared (NIR) light and biocompatible chromophores: cardiogreen, methylene blue, and riboflavin. All three chromophores are capable of significant photothermal reaction upon exposure to NIR and visible light, and the amount of temperature change is dependent upon light intensity, wavelength as well as chromophore concentration. Pulsatile release of bovine serum albumin (BSA) from thermally responsive hydrogels was achieved over 4 days. These findings have the potential to translate light-actuated drug delivery-on-demand systems from the bench to clinical applications that require explicit control over the presentation of biologically active molecules.

Indexed as

Drug Delivery SystemsHydrogelsIndocyanine GreenInfrared RaysLightMethylene BlueRiboflavinTemperatureHydrogelsIndocyanine GreenMethylene BlueRiboflavinCardiogreenMethylene blueNear-infrared lightPhotothermal effectRiboflavinTriggered releaseVisible light

Identifiers

PMID26423655
PMCPMC5016096
OpenAlexW2236527139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.