ArticleScientific reports2015
Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Food switching at a meal is positively associated with change in adiposity among children at high-familial risk for obesity.Appetite · 2025Article
- Mediation of genetic susceptibility to obesity through eating behaviours in children.Pediatric obesity · 2025Article
- Plant-Based vs. Animal-Based Diets: Appetitive Traits and Dietary Patterns in Adults Based on Cross-Sectional Surveys.Nutrients · 2025Article
- Psychometric evaluation of the Adult Eating Behavior Questionnaire and its relationship with body mass index among Chinese university students: a cross-sectional validation study.Frontiers in public health · 2025Article
- How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.BMC medicine · 2024Article
- Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects.Frontiers in nutrition · 2024Article
- Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children.International journal of obesity (2005) · 2024Article
- Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.International journal of epidemiology · 2023Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Validation of the Adult Eating Behaviour Questionnaire adapted for the French-speaking Canadian population.Eating and weight disorders : EWD · 2022Article
- Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.The Journal of nutrition · 2022Article
- Article
- Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence.Scientific reports · 2021Article
- Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.International journal of obesity (2005) · 2021Article
- Article
- Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.FASEB bioAdvances · 2021Article
- The Role of Eating Behaviours in Genetic Susceptibility to Obesity.Current obesity reports · 2020Review
- The genetic architecture of the association between eating behaviors and obesity: combining genetic twin modeling and polygenic risk scores.The American journal of clinical nutrition · 2020Article
- Common etiological architecture underlying reward responsiveness, externally driven eating behaviors, and BMI in childhood: findings from the Gemini twin cohort.International journal of obesity (2005) · 2020Article
- Eating behavior trajectories in the first 10 years of life and their relationship with BMI.International journal of obesity (2005) · 2020Article
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11 authors.
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Abstract
The mechanisms through which genes influence body weight are not well understood, but appetite has been implicated as one mediating pathway. Here we use data from two independent population-based Finnish cohorts (4632 adults aged 25-74 years from the DILGOM study and 1231 twin individuals aged 21-26 years from the FinnTwin12 study) to investigate whether two appetitive traits mediate the associations between known obesity-related genetic variants and adiposity. The results from structural equation modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measured body mass index and waist circumference are partly mediated through higher levels of uncontrolled eating (βindirect = 0.030-0.032, P < 0.001 in DILGOM) and emotional eating (βindirect = 0.020-0.022, P < 0.001 in DILGOM and βindirect = 0.013-0.015, P = 0.043-0.044 in FinnTwin12). Our findings suggest that genetic predispositions to obesity may partly exert their effects through appetitive traits reflecting lack of control over eating or eating in response to negative emotions. Obesity prevention and treatment studies should examine the impact of targeting these eating behaviours, especially among individuals having a high genetic predisposition to obesity.
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