ArticleNature communications2015
A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A blastoporal organizer in a ctenophore.Nature · 2026Article
- Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning.Nature communications · 2026Article
- Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian.Science advances · 2025Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
- Maternal TGF-β ligand Panda breaks the radial symmetry of the sea urchin embryo by antagonizing the Nodal type II receptor ACVRII.PLoS biology · 2024Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Article
- Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelidDevelopment (Cambridge, England) · 2020Article
- Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer.eLife · 2020Article
- Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates.Nature ecology & evolution · 2017Article
- The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions.Journal of visualized experiments : JoVE · 2017Article
- Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan.BMC developmental biology · 2017Article
- Article
- Cilia are required for asymmetric nodal induction in the sea urchin embryo.BMC developmental biology · 2016Article
- Acquisition of the dorsal structures in chordate amphioxus.Open biology · 2016Article
- Neurogenic gene regulatory pathways in the sea urchin embryo.Development (Cambridge, England) · 2016Article
- Developmental gene regulatory networks in sea urchins and what we can learn from them.F1000Research · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development of chordates, establishment of the body plan relies on the activity of an organizing centre located on the dorsal side of the embryo that patterns the embryo and induces neural tissue. Intriguingly, the evolutionary origin of this crucial signalling centre remains unclear and whether analogous organizers regulate D/V patterning in other deuterostome or protostome phyla is not known. Here we provide evidence that the ventral ectoderm of the sea urchin embryo is a long-range organizing centre that shares several fundamental properties with the Spemann organizer: the ability to induce duplicated embryonic axes when ectopically induced, the ability to induce neural fate in neighbouring tissues and the ability to finely regulate the level of BMP signalling by using an autoregulatory expansion-repression mechanism. These findings suggest that the evolutionary origin of the Spemann organizer is more ancient than previously thought and that it may possibly be traced back to the common ancestor of deuterostomes.
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