Evidence map›Paper›PMID 26423426›Full record

ArticleClinical rheumatology2015

Clinical and serologic features of primary Sjögren's syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study.

Wen Wen, Yanying Liu, Chuchu Zhao, Xiaolin Sun, Chunfang Zhang, Zhanguo Li

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wen WenDepartment of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11, Xizhimen South Street, Beijing, 100044, China.
Yanying LiuDepartment of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11, Xizhimen South Street, Beijing, 100044, China.
Chuchu ZhaoDepartment of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11, Xizhimen South Street, Beijing, 100044, China.
Xiaolin SunDepartment of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11, Xizhimen South Street, Beijing, 100044, China.
Chunfang ZhangDepartment of Clinical Epidemiology and Biostatistics, Peking University People's Hospital, Beijing, China.
Zhanguo LiDepartment of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11, Xizhimen South Street, Beijing, 100044, China. li99@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hemolytic anemia (AIHA) is an uncommon but clinically significant disorder in primary Sjögren's syndrome (pSS). Among 565 pSS patients hospitalized in Peking University People's Hospital from January 2000 to March 2013, 16 patients were diagnosed with AIHA (2.8% prevalence). AIHA presented at the onset of pSS without overt sicca symptoms in 3 of the 16 patients. Primary biliary cirrhosis (PBC) was more prevalent in the patients with SS-AIHA than in those without (p = 0.007). Edema, fever, and liver involvement occurred significantly more frequently in pSS patients with AIHA than those without AIHA (p = 0.035, p = 0.029, p = 0.024, respectively). The pSS patients with AIHA were more vulnerable to leukopenia and thrombocytopenia than those without AIHA (p = 0.004 and p = 0.001, respectively). Additionally, the levels of complement component 3 (C3) and complement component 4 (C4) were significantly lower in the SS-AIHA group (p = 0.008 and p = 0.037, respectively). Taken together, our results indicate that pSS should be considered in the differential diagnosis of AIHA, even in the absence of sicca symptoms. Among pSS patients, the existence of PBC, cytopenia, or hypocomplementemia suggests a higher risk of suffering from AIHA.

Indexed as

AdultAgedAnemia, Hemolytic, AutoimmuneBeijingComplement C3Complement C4Cross-Sectional StudiesFemaleHumansLeukopeniaLiver Cirrhosis, BiliaryMaleMiddle AgedRisk FactorsSjogren's SyndromeThrombocytopeniaComplement C3Complement C4AnemiaAutoimmunityCytopeniaPrimary biliary cirrhosisSjögren’s syndrome

Identifiers

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.