Trial reportThe lancet. HIV2015
Nurse-led palliative care for HIV-positive patients taking antiretroviral therapy in Kenya: a randomised controlled trial.
Trial report in The lancet. HIV, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01608802 (Phase 3 Trial of Palliative Care for HIV Patients on Antiretroviral Therapy), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 3 Trial of Palliative Care for HIV Patients on Antiretroviral Therapy
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- HIV-Specific Reported Outcome Measures: Systematic Review of Psychometric Properties.JMIR public health and surveillance · 2022Pooled it
- A systematic review of impact of person-centred interventions for serious physical illness in terms of outcomes and costs.BMJ open · 2022Pooled it
- Approaches to integrating palliative care into African health systems: a qualitative systematic review.Health policy and planning · 2020Pooled it
- The effectiveness and cost-effectiveness of hospital-based specialist palliative care for adults with advanced illness and their caregivers.The Cochrane database of systematic reviews · 2020Pooled it
- Comparing Specialty and Primary Palliative Care Interventions: Analysis of a Systematic Review.Journal of palliative medicine · 2020Pooled it
- Pooled it
- Active ingredients of a person-centred intervention for people on HIV treatment: analysis of mixed methods trial data.BMC infectious diseases · 2018Trial
- Trial
- How can integration of oncology and palliative care services be achieved for optimal patient benefit? Stakeholders' perspectives in Zimbabwe.The oncologist · 2026Article
- Contexts, mechanisms and outcomes of home-based palliative care implementation in low- and middle-income countries: A realist review.Palliative care and social practice · 2026Review
- Article
- Impact of Spiritual Support Interventions on the Quality of Life of Patients Who Receive Palliative Care: A Systematic Review.Nursing reports (Pavia, Italy) · 2024Review
- Palliative Care in Survivors of Critical Illness: A Qualitative Study of Post-Intensive Care Unit Program Clinicians.Journal of palliative medicine · 2023Article
- HIV and an Ageing Population-What Are the Medical, Psychosocial, and Palliative Care Challenges in Healthcare Provisions.Microorganisms · 2023Review
- Psychosocial Interventions by Nurses for Patients with HIV/ AIDS: A Systematic Review.Journal of caring sciences · 2023Review
- Positive Outcomes: Validity, reliability and responsiveness of a novel person-centred outcome measure for people with HIV.HIV medicine · 2022Article
- Building evidence and capacity in global health palliative care.Ecancermedicalscience · 2022Article
- Stakeholder perspectives and requirements to guide the development of digital technology for palliative cancer services: a multi-country, cross-sectional, qualitative study in Nigeria, Uganda and Zimbabwe.BMC palliative care · 2021Article
- An Integrative Framework of Appraisal and Adaptation in Serious Medical Illness.Journal of pain and symptom management · 2020Article
- Increased Retention in Care After a Palliative Care Referral Among People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPeople with HIV accessing antiretroviral therapy (ART) have persistent physical, psychological, social, and spiritual problems, which are associated with poor quality of life and treatment outcomes. We assessed the effectiveness of a nurse-led palliative care intervention on patient-reported outcomes.
methodsWe did this randomised controlled trial at a clinic in Kenya for adults with HIV, established on ART, and reporting moderate-to-severe pain or symptoms. We randomly assigned participants (1:1) either to a palliative care intervention (including assessments of physical, emotional, and spiritual wellbeing and quality of life) given six times over 4 months, or to usual care. Participants and investigators were not masked to allocation. The primary outcome was pain (scored on the African Palliative Care Association's African Palliative Outcome Scale). This trial is registered with ClinicalTrials.gov, number NCT01608802.
findingsWe screened 2070 patients, of whom we enrolled 120: 60 allocated to each group. In the control group, median pain score improved from 1·0 (IQR 0·0-2·0) at baseline to 5·0 (3·0-5·0) at 4 months; in the intervention group, it improved from 1·0 (0·0-2·0) at baseline to 4·5 (3·0-5·0) at 4 months. Compared with standard care, the intervention had no significant effect on pain (coefficient -0·01, 95% CI -0·36 to 0·34, p=0·95).
interpretationA nurse-led palliative care intervention was not effective in reducing pain. However, person-centred assessment and care delivered by staff who have received additional training had positive effects on self-reported mental health related quality of life and psychosocial wellbeing.
fundingDiana Princess of Wales Memorial Fund.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.