ArticleJournal of molecular neuroscience : MN2016
Serum Phenylalanine, Tyrosine, and their Ratio in Acute Ischemic Stroke: on the Trail of a Biomarker?
Article in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Time-dependent plasma metabolic shifts and mechanistic insights into systemic consequences of cerebral ischemia in middle-aged patients.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Metabolomic Profiling in Ischemic Stroke: Unraveling the Influence of Obesity and Identifying Potential Biomarkers UsingMolecular neurobiology · 2025Article
- Association of gut microbiota and immunometabolic profiles with ischemic stroke severity.Scientific reports · 2025Article
- Corroborated evidence on change of metabolome after ischemic stroke due to large vessel occlusion.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Association between peripheral blood serum phenylalanine to tyrosine ratio and the risk of moyamoya disease: a case-control study.Frontiers in neurology · 2025Article
- Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites.Biomedicines · 2024Article
- NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke.Metabolic brain disease · 2024Article
- Peripheral blood and urine metabolites and biological functions in post-stroke depression.Metabolic brain disease · 2022Article
- A Pilot Study on theAntioxidants (Basel, Switzerland) · 2021Article
- The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Assessment of serum phenylalanine and tyrosine isomers in patients with ST-segment elevation vs non-ST-segment elevation myocardial infarction.Journal of clinical laboratory analysis · 2021Article
- The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins.Antioxidants (Basel, Switzerland) · 2020Article
- Serum Metabolic Signatures of Chronic Limb-Threatening Ischemia in Patients with Peripheral Artery Disease.Journal of clinical medicine · 2020Article
- Altered Metabolomic Profile in Patients with Peripheral Artery Disease.Journal of clinical medicine · 2019Article
- Imprinted Oxide and MIP/Oxide Hybrid Nanomaterials for Chemical SensorsNanomaterials (Basel, Switzerland) · 2018Review
- Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms.Frontiers in neuroscience · 2018Review
- mir-193 targets ALDH2 and contributes to toxic aldehyde accumulation and tyrosine hydroxylase dysfunction in cerebral ischemia/reperfusion injury.Oncotarget · 2017Article
- Metabolic risk factors associated with sudden cardiac death (SCD) during acute myocardial ischemia.Forensic sciences research · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast diagnosis and appropriate treatment are of utmost importance to improving the outcome in patients with acute ischemic stroke (AIS). A rapid and sensitive blood test for ischemic stroke is required. The aim of this study was to examine the usefulness of phenylalanine (PHE) and tyrosine (TYR) as diagnostic biomarkers in AIS. Serum levels of PHE and TYR, measured using HPLC, and their ratio (PHE/TYR) were compared between 45 patients with AIS and 40 healthy control subjects. The relationship between PHE/TYR and the serum levels of several cytokines were also examined. PHE/TYR was significantly higher in AIS patients than in healthy controls (1.75 vs 1.24, p < 0.001). A receiver operating characteristic (ROC) curve analysis of PHE/TYR in AIS patients relative to healthy controls revealed promising sensitivity and specificity, which at an optimal cutoff of 1.45 were 76 and 85 %, respectively. PHE/TYR was positively correlated with interleukin (IL)-1β (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025). This study shows that PHE/TYR is highly elevated in the acute phase of AIS, and that this elevation is coupled to the inflammatory response. The ROC analysis documents the possible value of PHE/TYR as a biomarker for AIS and demonstrates its clinical potential as a blood-based test for AIS.
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