SynthesisEnvironmental science and pollution research international2015
Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case-control studies among individuals without occupational exposure history.
Synthesis in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Cadmium Exposure and Risk of Pancreatic Cancer: A Systematic Review and Meta-Analysis.La Medicina del lavoro · 2026Pooled it
- Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis.Occupational and environmental medicine · 2025Pooled it
- Prediagnostic whole-blood cadmium and molybdenum associated with pancreatic cancer in an American cohort.American journal of epidemiology · 2025Article
- Matching traditional Chinese medicine and western medicine-based research: Advanced nutraceutical development for proactive gastric cancer prevention.World journal of gastrointestinal oncology · 2024Review
- Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium.International journal of molecular sciences · 2024Review
- The dynamic face of cadmium-induced Carcinogenesis: Mechanisms, emerging trends, and future directions.Current research in toxicology · 2024Review
- Cadmium Toxicity and Health Effects-A Brief Summary.Molecules (Basel, Switzerland) · 2023Review
- Estimation of health risks associated with dietary cadmium exposure.Archives of toxicology · 2023Review
- Unboxing the molecular modalities of mutagens in cancer.Environmental science and pollution research international · 2022Review
- Health significant alarms of toxic carcinogenic risk consumption of blood meal metals contamination in poultry at a gold mining neighborhood, northern Thailand.Environmental geochemistry and health · 2022Article
- Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias.Exposure and health · 2022Article
- The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure.Frontiers in immunology · 2022Review
- Mercury in Pancreatic Cells of People with and without Pancreatic Cancer.International journal of environmental research and public health · 2020Article
- Effects of lead and cadmium on the immune system and cancer progression.Journal of environmental health science & engineering · 2020Review
- The Effects of Cadmium Toxicity.International journal of environmental research and public health · 2020Review
- Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma.Environmental and molecular mutagenesis · 2019Article
- Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer.International journal of molecular medicine · 2019Article
- Extract fromNutrients · 2018Article
- Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane.Toxicology and applied pharmacology · 2018Article
- Pancreatic cancer: Current status and Challenges.Current pharmacology reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Pancreatic cancer is one of the most deadly types of cancer for both genders. Classified as a human carcinogen, cadmium has been related to diverse cancers. However, the association between cadmium exposure and the risk of pancreatic cancer is still unclear. We quantitatively reviewed the observational studies on the association of cadmium exposure with pancreatic cancer risk among individuals without occupational exposure history published through July 2014 in PubMed by using a fixed-effect model. Four prospective cohort studies (112,934 participants with 335 events) and two case-control studies (177 cases and 539 controls) were identified. The summarized relative risk (RR) with a 95% confidence interval (CI) was 2.05 (95% CI = 1.58-2.66), comparing the highest to the lowest category of cadmium exposure. This positive association persisted in men (RR = 1.78, 95% CI = 1.04-3.05) but not in women (RR = 1.02, 95% CI = 0.63-1.65). Further research is needed to provide more solid evidence on the association of cadmium exposure with pancreatic cancer risk and to elucidate the underlying biological mechanism of the potential gender difference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.